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Literature summary extracted from
- Identification of two phospholipid hydroperoxide glutathione peroxidase (gpx4) genes in common carp (2009), Comp. Biochem. Physiol. C, 150, 101-106.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.11.1.12 | for sequencing | Cyprinus carpio |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.11.1.12 | selenium | - |
Cyprinus carpio |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.11.1.12 | glutathione + a lipid hydroperoxide | Cyprinus carpio | - |
glutathione disulfide + lipid + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.11.1.12 | Cyprinus carpio | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.11.1.12 | brain | - |
Cyprinus carpio | - |
| 1.11.1.12 | cerebellum | - |
Cyprinus carpio | - |
| 1.11.1.12 | heart | - |
Cyprinus carpio | - |
| 1.11.1.12 | kidney | - |
Cyprinus carpio | - |
| 1.11.1.12 | liver | - |
Cyprinus carpio | - |
| 1.11.1.12 | midbrain | - |
Cyprinus carpio | - |
| 1.11.1.12 | muscle | - |
Cyprinus carpio | - |
| 1.11.1.12 | olfactory lobe | - |
Cyprinus carpio | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.11.1.12 | glutathione + a lipid hydroperoxide | - |
Cyprinus carpio | glutathione disulfide + lipid + H2O | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.11.1.12 | monomer | - |
Cyprinus carpio |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.11.1.12 | GPx4A | - |
Cyprinus carpio |
| 1.11.1.12 | GPx4B | - |
Cyprinus carpio |
| 1.11.1.12 | phospholipid hydroperoxide glutathione peroxidase A | - |
Cyprinus carpio |
| 1.11.1.12 | phospholipid hydroperoxide glutathione peroxidase B | - |
Cyprinus carpio |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.11.1.12 | glutathione | - |
Cyprinus carpio | |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 1.11.1.12 | Cyprinus carpio | 10 mg/l Cd2+ down-regulates gpx4b in liver and olfactory lobe tissues | down |
| 1.11.1.12 | Cyprinus carpio | in the liver of the carp exposed to 7°C temperature drop, the gpx4a gene is down-regulated as early as 1 h after cold shock to 75% | down |
| 1.11.1.12 | Cyprinus carpio | in liver direct exposure to low temperature increases the transcription of gpx4b by 2.5fold | up |
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Release 2023.1 (January 2023)
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