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Literature summary extracted from

  • Sullivan, J.; Smart, E.; Pollock, D.; Pollock, J.
    Influence of salt on subcellular localization of nitric oxide synthase activity and expression in the renal inner medulla (2008), Clin. Exp. Pharmacol. Physiol., 35, 120-125.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.13.39 NG-Nitro-L-arginine complete inhibition at 1 mM, non-selective NOS inhibitor; complete inhibition at 1 mM, non-selective NOS inhibitor Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.13.39 cytosol
-
 Rattus norvegicus 5829
-
1.14.13.39 membrane total NOS activity is enriched in the intracellular membrane fraction at normal salt diet Rattus norvegicus 16020
-
1.14.13.39 plasma membrane
-
 Rattus norvegicus 5886
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.39 Rattus norvegicus P29476
-
-
1.14.13.39 Rattus norvegicus Q62600
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.39 kidney
-
 Rattus norvegicus
-
1.14.13.39 renal inner medulla
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.39 2 L-arginine + 3 NADPH + 3 H+ + 4 O2
-
 Rattus norvegicus 2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.13.39 NOS1 isozyme Rattus norvegicus
1.14.13.39 NOS3 isozyme Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.39 5,6,7,8-tetrahydro-L-biopterin 0.003 mM Rattus norvegicus
1.14.13.39 Calmodulin 30 nM Rattus norvegicus
1.14.13.39 NADPH 1 mM Rattus norvegicus

Expression

EC Number Organism Comment Expression
1.14.13.39 Rattus norvegicus expression of isozyme NOS1 protein is decreased in the cytoplasmic and plasma membrane fractions, although maintained in the intracellular membrane fraction, in response to high salt down
1.14.13.39 Rattus norvegicus expression of isozyme NOS3 protein is unaffected by high salt additional information