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Literature summary extracted from

  • Deiteren, K.; Hendriks, D.; Scharpe, S.; Lambeir, A.M.
    Carboxypeptidase M: Multiple alliances and unknown partners (2009), Clin. Chim. Acta, 399, 24-39.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.17.12 medicine patients with chronic persistent atrial fibrillation have reduced amounts of CPM mRNA and protein in the atrial tissue Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.17.12 expressed in HEK-293 cells, in Pichia pastoris, and in baculovirus-infected insect cells Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.4.17.12
-
 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.17.12 E264Q the mutation completely eliminates the CPM activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.12 1,10-phenanthroline
-
 Homo sapiens
3.4.17.12 1,4-dithiothreitol
-
 Homo sapiens
3.4.17.12 2-Guanidinoethylmercaptosuccinic acid strong CPM inhibitor Homo sapiens
3.4.17.12 2-mercaptomethyl-3-guanidinoethyl thiopropanoic acid strong CPM inhibitor Homo sapiens
3.4.17.12 Cd2+
-
 Homo sapiens
3.4.17.12 Co2+
-
 Homo sapiens
3.4.17.12 EDTA
-
 Homo sapiens
3.4.17.12 Zn2+
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.17.12 membrane
-
 Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.17.12 Zn2+ the catalytic center is located in the catalytic domain in a cavity with a funnel-like access that contains the catalytic Zn2+ ion Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.17.12 48000
-
 deglycosylated protein, calculated from amino acid sequence Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.17.12 additional information Homo sapiens using small substrates of the form benzoyl-Xaa-Arg CPM has the highest catalytic efficiency for substrates with the nonpolar aliphatic residues Ala and Met and aromatic amino acids (Phe, Tyr, Trp) in the penultimate place and the lowest with branched side chains (Ile) ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.12 Homo sapiens P14384
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.17.12 glycoprotein
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.12 adipocyte
-
 Homo sapiens
-
3.4.17.12 alveolar cell type I
-
 Homo sapiens
-
3.4.17.12 alveolar macrophage
-
 Homo sapiens
-
3.4.17.12 B-lymphocyte
-
 Homo sapiens
-
3.4.17.12 brain
-
 Homo sapiens
-
3.4.17.12 bronchoalveolar lavage fluid
-
 Homo sapiens
-
3.4.17.12 central nervous system
-
 Homo sapiens
-
3.4.17.12 chondrocyte
-
 Homo sapiens
-
3.4.17.12 dendritic cell
-
 Homo sapiens
-
3.4.17.12 endothelial cell
-
 Homo sapiens
-
3.4.17.12 epithelial cell
-
 Homo sapiens
-
3.4.17.12 fibroblast very low activity Homo sapiens
-
3.4.17.12 gastrointestinal tract
-
 Homo sapiens
-
3.4.17.12 glomerular mesangial cell
-
 Homo sapiens
-
3.4.17.12 granulocyte
-
 Homo sapiens
-
3.4.17.12 heart CPM mRNA expression is very low in the human heart Homo sapiens
-
3.4.17.12 hematopoietic cell
-
 Homo sapiens
-
3.4.17.12 kidney CPM expression is the highest in kidneys Homo sapiens
-
3.4.17.12 liver CPM mRNA expression is very low in the human liver Homo sapiens
-
3.4.17.12 lung CPM expression is the highest in lung membrane fractions Homo sapiens
-
3.4.17.12 macrophage CPM expression is the highest in macrophages Homo sapiens
-
3.4.17.12 mesenchymal cell
-
 Homo sapiens
-
3.4.17.12 mesenchymal stem cell
-
 Homo sapiens
-
3.4.17.12 osteoblast
-
 Homo sapiens
-
3.4.17.12 osteosarcoma cell
-
 Homo sapiens
-
3.4.17.12 pancreas CPM mRNA expression is very low in the human pancreas Homo sapiens
-
3.4.17.12 peripheral nervous system
-
 Homo sapiens
-
3.4.17.12 placenta CPM expression is the highest in placenta Homo sapiens
-
3.4.17.12 pulmonary artery endothelial cell
-
 Homo sapiens
-
3.4.17.12 seminal plasma
-
 Homo sapiens
-
3.4.17.12 skeletal muscle very low activity Homo sapiens
-
3.4.17.12 T-lymphocyte
-
 Homo sapiens
-
3.4.17.12 U2-OS cell
-
 Homo sapiens
-
3.4.17.12 urine
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.12 benzoyl-Gly-argininic acid + H2O
-
 Homo sapiens benzoyl-Gly + argininic acid
-
 ?
3.4.17.12 benzoyl-Gly-L-Arg + H2O
-
 Homo sapiens benzoyl-Gly + L-Arg
-
 ?
3.4.17.12 benzoyl-L-Asn-L-Arg + H2O
-
 Homo sapiens benzoyl-L-Asn + L-Arg
-
 ?
3.4.17.12 dansyl-L-Ala-L-Arg + H2O
-
 Homo sapiens dansyl-L-Ala + L-Arg
-
 ?
3.4.17.12 Hippuryl-L-Lys + H2O
-
 Homo sapiens Hippuric acid + L-Lys
-
 ?
3.4.17.12 additional information using small substrates of the form benzoyl-Xaa-Arg CPM has the highest catalytic efficiency for substrates with the nonpolar aliphatic residues Ala and Met and aromatic amino acids (Phe, Tyr, Trp) in the penultimate place and the lowest with branched side chains (Ile) Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.17.12 monomer 1 * 48000, X-ray crystallography Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.17.12 CPM
-
 Homo sapiens