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Literature summary extracted from

  • Nguyen, L.P.; Hsu, E.L.; Chowdhury, G.; Dostalek, M.; Guengerich, F.P.; Bradfield, C.A.
    D-amino acid oxidase generates agonists of the aryl hydrocarbon receptor from D-tryptophan (2009), Chem. Res. Toxicol., 22, 1897-1904.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.3.3 expression of recombinant enzyme, using the CYP1A1 promoter, in murine hepatoma Hepa1c1c7 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.3 beta-naphthoflavone
-
 Homo sapiens
1.4.3.3 beta-naphthoflavone
-
 Sus scrofa
1.4.3.3 Sodium benzoate inhibits the enzyme activity by by impeding the interaction of the enzyme with the flavin prosthetic group Homo sapiens
1.4.3.3 Sodium benzoate inhibits the enzyme activity by impeding the interaction of the enzyme with the flavin prosthetic group Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.3 D-tryptophan + H2O + O2 Homo sapiens DAAO catalyzes the production of aryl hydrocarbon receptor, AHR, agonists through the enzymatic conversion of D-tryptophan to indole-3-pyruvic acid indole-3-pyruvic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-tryptophan + H2O + O2 Sus scrofa DAAO catalyzes the production of aryl hydrocarbon receptor, AHR, agonists through the enzymatic conversion of D-tryptophan to indole-3-pyruvic acid indole-3-pyruvic acid + NH3 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.3 Homo sapiens
-
-
-
1.4.3.3 Sus scrofa P00371
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.3 commercial preparation
-
 Sus scrofa
-
1.4.3.3 hepatoma cell line 101L cell Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.3 D-tryptophan + H2O + O2
-
 Homo sapiens indole-3-pyruvic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-tryptophan + H2O + O2
-
 Sus scrofa indole-3-pyruvic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-tryptophan + H2O + O2 DAAO catalyzes the production of aryl hydrocarbon receptor, AHR, agonists through the enzymatic conversion of D-tryptophan to indole-3-pyruvic acid Homo sapiens indole-3-pyruvic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-tryptophan + H2O + O2 DAAO catalyzes the production of aryl hydrocarbon receptor, AHR, agonists through the enzymatic conversion of D-tryptophan to indole-3-pyruvic acid Sus scrofa indole-3-pyruvic acid + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.3 DAAO
-
 Homo sapiens
1.4.3.3 DAAO
-
 Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.4.3.3 7.4
-
 assay at Homo sapiens
1.4.3.3 7.4
-
 assay at Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.3 FAD
-
 Homo sapiens
1.4.3.3 FAD
-
 Sus scrofa

General Information

EC Number General Information Comment Organism
1.4.3.3 physiological function the enzymatic function of DAAO is required for AHR activation by D-Trp and D-Tyr. DAAO catalyzes the production of aryl hydrocarbon receptor, AHR, agonists through the enzymatic conversion of D-tryptophan to indole-3-pyruvic acid, followed by nonenzymatic oxidation and condensation of indole-3-pyruvic acid is a critical step in the generation of receptor agonists by DAAO and aspartate aminotransferase, AST. Products of this process include the two agonists, 1,3-di(1H-indol-3-yl)propan-2-one and 1-(1H-indol-3-yl)-3-(3H-indol- 3-ylidene) propan-2-one, overview Homo sapiens
1.4.3.3 physiological function the enzymatic function of DAAO is required for AHR activation by D-Trp and D-Tyr. DAAO catalyzes the production of aryl hydrocarbon receptor, AHR, agonists through the enzymatic conversion of D-tryptophan to indole-3-pyruvic acid, followed by nonenzymatic oxidation and condensation of indole-3-pyruvic acid is a critical step in the generation of receptor agonists by DAAO and aspartate aminotransferase, AST. Products of this process include the two agonists, 1,3-di(1H-indol-3-yl)propan-2-one and 1-(1H-indol-3-yl)-3-(3H-indol- 3-ylidene) propan-2-one, overview Sus scrofa