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Literature summary extracted from

  • Peplowski, L.; Kubiak, K.; Nowak, W.
    Mechanical aspects of nitrile hydratase enzymatic activity. Steered molecular dynamics simulations of Pseudonocardia thermophila JCM 3095 (2008), Chem. Phys. Lett., 467, 144-149.
No PubMed abstract available

Application

EC Number Application Comment Organism
4.2.1.84 synthesis nitrile hydratase is used for large scale industrial production of important commodities such as acrylamide and nicotinamide Pseudonocardia thermophila

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.2.1.84 dockings of the substrates and products to the crystal structure 1IRE, overview Pseudonocardia thermophila

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.1.84 additional information nitrile hydratase is a metalloenzyme Pseudonocardia thermophila

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.84 acrylonitrile + H2O Pseudonocardia thermophila
-
 acrylamide
-
 ?
4.2.1.84 acrylonitrile + H2O Pseudonocardia thermophila JCM 3095
-
 acrylamide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.84 Pseudonocardia thermophila
-
-
-
4.2.1.84 Pseudonocardia thermophila JCM 3095
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.84 acrylonitrile + H2O
-
 Pseudonocardia thermophila acrylamide
-
 ?
4.2.1.84 acrylonitrile + H2O stereoselective reaction Pseudonocardia thermophila acrylamide
-
 ?
4.2.1.84 acrylonitrile + H2O
-
 Pseudonocardia thermophila JCM 3095 acrylamide
-
 ?
4.2.1.84 acrylonitrile + H2O stereoselective reaction Pseudonocardia thermophila JCM 3095 acrylamide
-
 ?
4.2.1.84 additional information computational molecular dynamics modelling of ligand docking and substrate transport and binding, overview Pseudonocardia thermophila ?
-
 ?
4.2.1.84 additional information computational molecular dynamics modelling of ligand docking and substrate transport and binding, overview Pseudonocardia thermophila JCM 3095 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.84 NHase
-
 Pseudonocardia thermophila