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Literature summary extracted from

  • Yi, W.; Cao, R.H.; Chen, Z.Y.; Yu, L.; Ma, L.; Song, H.C.
    Design, synthesis and biological evaluation of hydroxy- or methoxy-substituted phenylmethylenethiosemicarbazones as tyrosinase inhibitors (2009), Chem. Pharm. Bull., 57, 1273-1277.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 2-(2-furanylmethylene)-thiosemicarbazone
-
 Agaricus bisporus
1.14.18.1 2-(phenylmethylene)-thiosemicarbazone
-
 Agaricus bisporus
1.14.18.1 2-[(2,3,4-trihydroxyphenyl)methylene]-thiosemicarbazone
-
 Agaricus bisporus
1.14.18.1 2-[(2,4-dihydroxyphenyl)methylene]-thiosemicarbazone most potent tyrosinase inhibitor Agaricus bisporus
1.14.18.1 2-[(2,5-dihydroxyphenyl)methylene]-thiosemicarbazone
-
 Agaricus bisporus
1.14.18.1 2-[(2,5-dimethoxyphenyl)methylene]-thiosemicarbazone
-
 Agaricus bisporus
1.14.18.1 2-[(2-hydroxy-4-bromophenyl)methylene]thiosemicarbazone
-
 Agaricus bisporus
1.14.18.1 2-[(2-hydroxyphenyl)methylene]-thiosemicarbazone
-
 Agaricus bisporus
1.14.18.1 2-[(3,4,5-trihydroxyphenyl)methylene]-thiosemicarbazone
-
 Agaricus bisporus
1.14.18.1 2-[(3,4,5-trimethoxyphenyl)methylene]-thiosemicarbazone
-
 Agaricus bisporus
1.14.18.1 2-[(3,4-dihydroxyphenyl)methylene]-thiosemicarbazone
-
 Agaricus bisporus
1.14.18.1 2-[(3,5-dihydroxyphenyl)methylene]-thiosemicarbazone
-
 Agaricus bisporus
1.14.18.1 2-[(3-hydroxy-4-methoxyphenyl)methylene]-thiosemicarbazone
-
 Agaricus bisporus
1.14.18.1 2-[(3-hydroxyphenyl)methylene]-thiosemicarbazone
-
 Agaricus bisporus
1.14.18.1 2-[(3-methoxy-4-hydroxyphenyl)methylene]-thiosemicarbazone
-
 Agaricus bisporus
1.14.18.1 2-[(4-bromophenyl)methylene]-thiosemicarbazone
-
 Agaricus bisporus
1.14.18.1 2-[(4-hydroxyphenyl)methylene]-thiosemicarbazone
-
 Agaricus bisporus
1.14.18.1 2-[(4-methoxyphenyl)methylene]-thiosemicarbazone
-
 Agaricus bisporus
1.14.18.1 4-hydroxybenzaldehyde
-
 Agaricus bisporus
1.14.18.1 4-methoxycinnamic acid
-
 Agaricus bisporus
1.14.18.1 Thiosemicarbazide
-
 Agaricus bisporus
1.14.18.1 tropolone
-
 Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-Dopa + O2
-
 Agaricus bisporus L-dopaquinone + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 polyphenol oxidase
-
 Agaricus bisporus
1.14.18.1 PPO
-
 Agaricus bisporus
1.14.18.1 tyrosinase
-
 Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 0.00018
-
 in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(2,4-dihydroxyphenyl)methylene]-thiosemicarbazone
1.14.18.1 0.00028
-
 in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(4-bromophenyl)methylene]-thiosemicarbazone
1.14.18.1 0.00033
-
 in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(2-hydroxy-4-bromophenyl)methylene]thiosemicarbazone
1.14.18.1 0.00038
-
 in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(2-hydroxyphenyl)methylene]-thiosemicarbazone
1.14.18.1 0.00041
-
 in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(4-hydroxyphenyl)methylene]-thiosemicarbazone
1.14.18.1 0.00042
-
 in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus tropolone
1.14.18.1 0.00045
-
 in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-(2-furanylmethylene)-thiosemicarbazone
1.14.18.1 0.00148
-
 in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(4-methoxyphenyl)methylene]-thiosemicarbazone
1.14.18.1 0.00193
-
 in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-(phenylmethylene)-thiosemicarbazone
1.14.18.1 0.0039
-
 in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(3-hydroxyphenyl)methylene]-thiosemicarbazone
1.14.18.1 0.00488
-
 in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(3-hydroxy-4-methoxyphenyl)methylene]-thiosemicarbazone
1.14.18.1 0.00568
-
 in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(3-methoxy-4-hydroxyphenyl)methylene]-thiosemicarbazone
1.14.18.1 0.0065
-
 in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(2,5-dihydroxyphenyl)methylene]-thiosemicarbazone
1.14.18.1 0.0336
-
 in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(3,5-dihydroxyphenyl)methylene]-thiosemicarbazone
1.14.18.1 0.0422
-
 in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(3,4-dihydroxyphenyl)methylene]-thiosemicarbazone
1.14.18.1 0.0875
-
 in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(2,5-dimethoxyphenyl)methylene]-thiosemicarbazone
1.14.18.1 0.1152
-
 in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(3,4,5-trihydroxyphenyl)methylene]-thiosemicarbazone
1.14.18.1 0.1455
-
 in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(3,4,5-trimethoxyphenyl)methylene]-thiosemicarbazone
1.14.18.1 0.2
-
 IC50 above 0.2 mM, in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(2,3,4-trihydroxyphenyl)methylene]-thiosemicarbazone
1.14.18.1 0.41
-
 in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 4-methoxycinnamic acid
1.14.18.1 1.22
-
 in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 4-hydroxybenzaldehyde
1.14.18.1 2
-
 IC50 aboe 2.0 mM, in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus Thiosemicarbazide