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Literature summary extracted from

  • Zhao, B.; Chu, Y.; Huang, Y.; Hardy, D.O.; Lin, S.; Ge, R.S.
    Structure-dependent inhibition of human and rat 11beta-hydroxysteroid dehydrogenase 2 activities by phthalates (2010), Chem. Biol. Interact., 183, 79-84.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.B40 di-n-butyl phthalate
-
 Homo sapiens
1.1.1.B40 di-n-butyl phthalate
-
 Rattus norvegicus
1.1.1.B40 di-n-octyl phthalate
-
 Homo sapiens
1.1.1.B40 di-n-octyl phthalate
-
 Rattus norvegicus
1.1.1.B40 di-n-pentyl phthalate
-
 Homo sapiens
1.1.1.B40 di-n-pentyl phthalate
-
 Rattus norvegicus
1.1.1.B40 dicyclohexyl phthalate
-
 Homo sapiens
1.1.1.B40 dicyclohexyl phthalate
-
 Rattus norvegicus
1.1.1.B40 diethyl phthalate
-
 Homo sapiens
1.1.1.B40 diethyl phthalate
-
 Rattus norvegicus
1.1.1.B40 dipropyl phthalate
-
 Homo sapiens
1.1.1.B40 dipropyl phthalate
-
 Rattus norvegicus
1.1.1.B40 mono (2-ethylhexyl) phthalate competitive inhibitor of 11beta-HSD2, possibly via competing with the cofactor NAD+ Homo sapiens
1.1.1.B40 mono (2-ethylhexyl) phthalate competitive inhibitor of 11beta-HSD2, possibly via competing with the cofactor NAD+ Rattus norvegicus
1.1.1.B40 additional information not inhibited by dimethyl phthalate, butylbenzyl phthalate, di(2-ethylhexyl) phthalate, di-n-heptyl phthalate, diisononyl phthalate, and diisodecyl phthalate Homo sapiens
1.1.1.B40 additional information not inhibited by dimethyl phthalate, butylbenzyl phthalate, di(2-ethylhexyl) phthalate, di-n-heptyl phthalate, diisononyl phthalate, and diisodecyl phthalate Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.B40 microsome
-
 Homo sapiens
-
-
1.1.1.B40 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.B40 Homo sapiens
-
-
-
1.1.1.B40 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.B40 kidney
-
 Homo sapiens
-
1.1.1.B40 kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.B40 corticosterone + NAD+
-
 Homo sapiens 11-dehydrocorticosterone + NADH + H+
-
 ?
1.1.1.B40 corticosterone + NAD+
-
 Rattus norvegicus 11-dehydrocorticosterone + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.B40 11beta-HSD2
-
 Homo sapiens
1.1.1.B40 11beta-HSD2
-
 Rattus norvegicus
1.1.1.B40 11beta-hydroxysteroid dehydrogenase 2
-
 Homo sapiens
1.1.1.B40 11beta-hydroxysteroid dehydrogenase 2
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.B40 NAD+
-
 Homo sapiens
1.1.1.B40 NAD+
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.B40 0.01369
-
-
 Rattus norvegicus di-n-butyl phthalate
1.1.1.B40 0.03264
-
-
 Rattus norvegicus dicyclohexyl phthalate
1.1.1.B40 0.08559
-
-
 Rattus norvegicus dipropyl phthalate
1.1.1.B40 0.1108
-
-
 Homo sapiens mono (2-ethylhexyl) phthalate
1.1.1.B40 0.1218
-
-
 Rattus norvegicus mono (2-ethylhexyl) phthalate