Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Katz, D.J.; Edwards, T.M.; Reinke, V.; Kelly, W.G.
    A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory (2009), Cell, 137, 308-320.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.14.99.66 additional information The amx-1(ok659) and T08D10.2 mutations are deletion alleles, whereas spr-5(by101) is a Tc3 transposon insertion in the middle of the conserved amine-oxidase catalytic domain. This transposon insertion is predicted to abolish the demethylase activity of the amine oxidase domain. Mutants in spr-5 exhibit progressive sterility over many generations. This sterility correlates with the misregulation of spermatogenesis-expressed genes and transgenerational accumulation of the histone modification. Lack of demethylase activity results in germline mortality, detailed overview Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.99.66 [histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2 Caenorhabditis elegans
-
 [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.66 Caenorhabditis elegans
-
 three lsd1/kdm1 homologues encoded by the genes spr-5, amx-1, and T08D10.2
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.66 [histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2
-
 Caenorhabditis elegans [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.99.66 H3K4me2 demethylase
-
 Caenorhabditis elegans
1.14.99.66 LSD1
-
 Caenorhabditis elegans
1.14.99.66 LSD1 demethylase
-
 Caenorhabditis elegans
1.14.99.66 LSD1/KDM1
-
 Caenorhabditis elegans
1.14.99.66 SPR-5
-
 Caenorhabditis elegans

General Information

EC Number General Information Comment Organism
1.14.99.66 physiological function LSD1 contributes to germline immortality by reprogramming epigenetic memory, H3K4me2 can serve as a stable epigenetic memory, erasure of H3K4me2 by LSD/KDM1 in the germline prevents the inappropriate transmission of this epigenetic memory from one generation to the next Caenorhabditis elegans