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Literature summary extracted from

  • Hopper-Borge, E.; Xu, X.; Shen, T.; Shi, Z.; Chen, Z.S.; Kruh, G.D.
    Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B (2009), Cancer Res., 69, 178-184.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.6.2.2 MRP7 expression in HEK-293 cells, ectopic expression of MRP7 in mouse embryonic fibroblast deficient in P-glycoprotein and MRP1 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.6.2.2 additional information no inhibition by buthionine sulfoximine Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.2 membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.2 ATP + H2O + xenobiotic/in Homo sapiens the enzyme increases the resistance level of cells against drugs, overview ADP + phosphate + xenobiotic/out
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.2 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.2 ATP + H2O + 2',3'-dideoxycytidine/in
-
 Homo sapiens ADP + phosphate + 2',3'-dideoxycytidine/out
-
 ?
7.6.2.2 ATP + H2O + cytarabine/in
-
 Homo sapiens ADP + phosphate + cytarabine/out
-
 ?
7.6.2.2 ATP + H2O + daunorubicin/in
-
 Homo sapiens ADP + phosphate + daunorubicin/out
-
 ?
7.6.2.2 ATP + H2O + docetaxel/in
-
 Homo sapiens ADP + phosphate + docetaxel/out
-
 ?
7.6.2.2 ATP + H2O + epothilone B/in
-
 Homo sapiens ADP + phosphate + epothilone B/out
-
 ?
7.6.2.2 ATP + H2O + etoposide/in
-
 Homo sapiens ADP + phosphate + etoposide/out
-
 ?
7.6.2.2 ATP + H2O + gemcitabine/in
-
 Homo sapiens ADP + phosphate + gemcitabine/out
-
 ?
7.6.2.2 ATP + H2O + p-methoxy-ethylamphetamine/in
-
 Homo sapiens ADP + phosphate + p-methoxy-ethylamphetamine/out
-
 ?
7.6.2.2 ATP + H2O + paclitaxel/in
-
 Homo sapiens ADP + phosphate + paclitaxel/out
-
 ?
7.6.2.2 ATP + H2O + SN-38/in
-
 Homo sapiens ADP + phosphate + SN-38/out
-
 ?
7.6.2.2 ATP + H2O + vincristine/in
-
 Homo sapiens ADP + phosphate + vincristine/out
-
 ?
7.6.2.2 ATP + H2O + xenobiotic/in
-
 Homo sapiens ADP + phosphate + xenobiotic/out
-
 ?
7.6.2.2 ATP + H2O + xenobiotic/in the enzyme increases the resistance level of cells against drugs, overview Homo sapiens ADP + phosphate + xenobiotic/out
-
 ?
7.6.2.2 additional information MRP7 has a broad resistance profile for natural products, no transport activity with nontaxane antimicrotubule agents Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.6.2.2 ABCC10
-
 Homo sapiens
7.6.2.2 MRP7
-
 Homo sapiens
7.6.2.2 multidrug resistance protein 7
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
7.6.2.2 37
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
7.6.2.2 ATP
-
 Homo sapiens