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Literature summary extracted from

  • Hughes, D.; Otani, T.; Yang, P.; Newman, R.A.; Yantiss, R.K.; Altorki, N.K.; Port, J.L.; Yan, M.; Markowitz, S.D.; Mazumdar, M.; Tai, H.H.; Subbaramaiah, K.; Dannenberg, A.J.
    NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer (2008), Cancer Prev. Res. (Phila.), 1, 241-249.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.141 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.141 lung
-
 Homo sapiens
-
1.1.1.141 non-small cell lung cancer cell reduced expression of 15-PGDH occurrs in tumor cells and is paralleled by decreased 15-PGDH activity in tumors Homo sapiens
-
1.1.1.141 non-small cell lung cancer cell the amount of 15-PGDH is frequently decreased in NSCLC cells compared with adjacent normal lung Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.141 prostaglandin E1 + NAD+
-
 Homo sapiens 15-ketoprostaglandin E1 + NADH + H+
-
 ?
1.1.1.141 prostaglandin E2 + NAD+
-
 Homo sapiens 15-ketoprostaglandin E2 + NADH + H+
-
 ?
1.1.1.141 prostaglandin F2alpha + NAD+
-
 Homo sapiens 15-ketoprostaglandin F2alpha + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.141 15-PGDH
-
 Homo sapiens
1.1.1.141 NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.141 NAD+ dependent on Homo sapiens