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Literature summary extracted from

  • Azab, S.S.; Salama, S.A.; Abdel-Naim, A.B.; Khalifa, A.E.; El-Demerdash, E.; Al-Hendy, A.
    2-Methoxyestradiol and multidrug resistance: can 2-methoxyestradiol chemosensitize resistant breast cancer cells? (2009), Breast Cancer Res. Treat., 113, 9-19.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.22.56 2-methoxyestradiol increases the enzyme activity 2fold at 100 nM Homo sapiens
3.4.22.56 doxorubicin augments caspase-3 activity Homo sapiens
3.4.22.56 doxorubicin/2-methoxyestradiol both in combination activate the enzyme 27fold Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.56 DEVD-fluoromethyl ketone
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.56 additional information Homo sapiens caspase-3 is playing a central role in the execution of apoptosis, its activation induces Dox resistance, mechanism, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.56 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.56 breast cancer cell a breast cancer Dox resistant MCF-7/Dox cell line Homo sapiens
-
3.4.22.56 MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.56 DEVD-7-amido-4-fluoromethylcoumarin + H2O
-
 Homo sapiens DEVD + 7-amino-4-fluoromethylcoumarin
-
 ?
3.4.22.56 additional information caspase-3 is playing a central role in the execution of apoptosis, its activation induces Dox resistance, mechanism, overview Homo sapiens ?
-
 ?