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Literature summary extracted from

  • Keeble, J.E.
    Re-sensitization of neuropeptide receptors: should we stop the recycling? (2009), Br. J. Pharmacol., 156, 728-729.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.4.24.71 drug development ECE-1 is a potential target for the treatment of Alzheimer’s disease based on its role in amyloid-beta peptide degradation Homo sapiens
3.4.24.71 drug development Inhibition of endothelin-1 production by ECE-1 is a promising target for the treatment of cardiovascular disease, but lack of substrate specificity is disadvantageous since inhibition of ECE-1 has impact on other pathways too Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.71 endosome
-
 Homo sapiens 5768
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.71 amyloid-beta peptide + H2O Homo sapiens
-
 ?
-
 ?
3.4.24.71 big endothelin-1 + H2O Homo sapiens
-
 endothelin-1 + ?
-
 ?
3.4.24.71 bradykinin + H2O Homo sapiens
-
 ?
-
 ?
3.4.24.71 Substance P + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.71 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.24.71 Hydrolysis of the -Trp21-/-Val- bond in big endothelin to form endothelin 1 ECE-1 promotes the recycling and re-sensitization of NK1 receptors, by degrading endocytosed substance P in endothelial cell endosomes. ECE-1 promotes CGRP and somatostatin receptor recycling Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.71 endothelial cell ECE-1 is very abundant Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.71 amyloid-beta peptide + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.71 big endothelin-1 + H2O
-
 Homo sapiens endothelin-1 + ?
-
 ?
3.4.24.71 bradykinin + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.71 Substance P + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.71 ECE-1
-
 Homo sapiens
3.4.24.71 endothelin-converting enzyme 1
-
 Homo sapiens