EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.12.98.2 | Fe | Hmd holoenzyme is comprised of 2 iron atoms, each iron atom coordinates the reduction of methenyltetrahydromethanopterin and oxidation of H2 while bound to both Hmd and a cofactor molecule | Methanocaldococcus jannaschii |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.12.98.2 | 38000 | - |
the Hmd holoenzyme is comprised of a homodimer of 38 kDa subunits, 2 pyridone derivative cofactor molecules and 2 iron atoms | Methanocaldococcus jannaschii |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.12.98.2 | 5,10-methenyltetrahydromethanopterin + H2 | Methanocaldococcus jannaschii | Hmd catalyzes a step in the hydrogenotrophic methanogenesis pathway in class I methanogens | 5,10-methylenetetrahydromethanopterin + H+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.12.98.2 | Methanocaldococcus jannaschii | Q58194 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.12.98.2 | 5,10-methenyltetrahydromethanopterin + H2 | Hmd catalyzes a step in the hydrogenotrophic methanogenesis pathway in class I methanogens | Methanocaldococcus jannaschii | 5,10-methylenetetrahydromethanopterin + H+ | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.12.98.2 | homodimer | 2 * 38000, structural modeling of Hmd enzyme reveals a common structural arrangement comprised of one large N-terminal domain containing alpha-helices and beta-sheets and one smaller C-terminal domain containing only alpha-helices | Methanocaldococcus jannaschii |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.12.98.2 | H2-forming methylenetetrahydromethanopterin dehydrogenase | - |
Methanocaldococcus jannaschii |
1.12.98.2 | Hmd | - |
Methanocaldococcus jannaschii |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.12.98.2 | coenzyme F420 | - |
Methanocaldococcus jannaschii |