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Literature summary extracted from

  • Boccalatte, F.E.; Voena, C.; Riganti, C.; Bosia, A.; DAmico, L.; Riera, L.; Cheng, M.; Ruggeri, B.; Jensen, O.N.; Goss, V.L.; Lee, K.; Nardone, J.; Rush, J.; Polakiewicz, R.D.; Comb, M.J.; Chiarle, R.; Inghirami, G.
    The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL (2009), Blood, 113, 2776-2790.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.2.3 additional information enzyme phosphorylation by anaplastic lymphoma kinase enhances enzymatic activity and dampens the methotrexate-mediated transformylase activity inhibition Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.2.3 methotrexate enzyme phosphorylation dampens the methotrexate-mediated transformylase activity inhibition Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.10 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide + H2O Homo sapiens catalyzation of the final two steps of de novo purine biosynthesis pathway ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.3 Homo sapiens P31939 bifunctional 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
-
3.5.4.10 Homo sapiens P31939
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.1.2.3 phosphoprotein bifunctional 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase associates with nucleoplasmin-anaplastic lymphoma kinase, and its phosphorylation requires anaplastic lymphoma kinase activity. Phosphorylation enhances enzymatic activity and dampens the methotrexate-mediated transformylase activity inhibition Homo sapiens
3.5.4.10 phosphoprotein phophorylation increases enzyme activity Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.2.3 CCRF-CEM cell
-
 Homo sapiens
-
2.1.2.3 JURKAT cell
-
 Homo sapiens
-
2.1.2.3 Mac-1 cell
-
 Homo sapiens
-
2.1.2.3 SUP-M2 cell
-
 Homo sapiens
-
2.1.2.3 Sup-M2-TS cell
-
 Homo sapiens
-
3.5.4.10 anaplastic large cell lymphoma cell ALCL cell line TS, Sup-M2 cells, JB-6 cells, SU-DHL1 cells Homo sapiens
-
3.5.4.10 CCRF-CEM cell
-
 Homo sapiens
-
3.5.4.10 HEK-293T cell immunoprecipitated from Homo sapiens
-
3.5.4.10 JURKAT cell
-
 Homo sapiens
-
3.5.4.10 KARPAS-299 cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.4.10 additional information
-
 proteomic approach to identify phophorylated proteins with a pathogenic role in transformation mediated by anaplastic lymphoma kinase (ALK), profiling of tyrosine-phosphorylation, mass spectrometry, anti-phosphotyrosine protein immunoprecipitation, posttranslational modification of the bifunctional 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) formyltransferase/inosine monophosphate (IMP) cyclohydrolase (AICAR-FT/IMP-CHase, ATIC) by phosphorylation, enzyme is a direct target of anaplastic lymphoma kinase (ALK), phoshorylation increases enzyme activity posttranslational modification of a key purine synthesis enzyme Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.10 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide + H2O catalyzation of the final two steps of de novo purine biosynthesis pathway Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.4.10 AICAR-FT/IMP-CHase
-
 Homo sapiens
3.5.4.10 ATIC
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.4.10 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.4.10 7.5
-
 assay at Homo sapiens