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Literature summary extracted from

  • Dorai, H.; Kyung, Y.S.; Ellis, D.; Kinney, C.; Lin, C.; Jan, D.; Moore, G.; Betenbaugh, M.J.
    Expression of anti-apoptosis genes alters lactate metabolism of chinese hamster ovary cells in culture (2009), Biotechnol. Bioeng., 103, 592-608.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.22.56 additional information staurosporine induces the enzyme Cricetulus griseus
3.4.22.60 additional information staurosporine induces the enzyme Cricetulus griseus

Application

EC Number Application Comment Organism
3.4.22.56 molecular biology engineering of CHO cells for more robust cell lines includes reduction of apoptotic capase-3, overview Cricetulus griseus
3.4.22.60 molecular biology engineering of CHO cells for more robust cell lines includes reduction of apoptotic capase-7, overview Cricetulus griseus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.22.56 additional information engineering of CHO cells for more robust cell lines includes reduction of apoptotic capase-3, activities in different mutant cell lines, overview. The cells exhibit a reduction in caspase 3 activity of at least 60% and a 170% enhancement in mitochondrial membrane potential compared to controls when treated with staurosporine Cricetulus griseus
3.4.22.60 additional information engineering of CHO cells for more robust cell lines includes reduction of apoptotic capase-7, activities in different mutant cell lines, overview Cricetulus griseus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.56 XIAP inhibitors peptide inhibitors Cricetulus griseus
3.4.22.60 XIAP inhibitors peptide inhibitors Cricetulus griseus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.56 additional information Cricetulus griseus apoptosis is a result of a complex network of signaling pathways initiating from both inside and outside the cell, culminating in the activation of caspases, cyteine aspartate proteases, that execute the final stages of cell death ?
-
 ?
3.4.22.60 additional information Cricetulus griseus apoptosis is a result of a complex network of signaling pathways initiating from both inside and outside the cell, culminating in the activation of caspases, cyteine aspartate proteases, that execute the final stages of cell death ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.56 Cricetulus griseus
-
-
-
3.4.22.60 Cricetulus griseus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.56 CHO cell
-
 Cricetulus griseus
-
3.4.22.60 CHO cell
-
 Cricetulus griseus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.56 additional information apoptosis is a result of a complex network of signaling pathways initiating from both inside and outside the cell, culminating in the activation of caspases, cyteine aspartate proteases, that execute the final stages of cell death Cricetulus griseus ?
-
 ?
3.4.22.56 N-carbobenzyloxy-DEVD-R110 + H2O a fluorescent substrate Cricetulus griseus ?
-
 ?
3.4.22.60 additional information apoptosis is a result of a complex network of signaling pathways initiating from both inside and outside the cell, culminating in the activation of caspases, cyteine aspartate proteases, that execute the final stages of cell death Cricetulus griseus ?
-
 ?
3.4.22.60 N-carbobenzyloxy-DEVD-R110 + H2O a fluorescent substrate Cricetulus griseus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.56 caspase 3
-
 Cricetulus griseus