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Literature summary extracted from

  • Chiku, K.; Dohi, H.; Saito, A.; Ebise, H.; Kouzai, Y.; Shinoyama, H.; Nishida, Y.; Ando, A.
    Enzymatic synthesis of 4-hydroxyphenyl beta-D-oligoxylosides and their notable tyrosinase inhibitory activity (2009), Biosci. Biotechnol. Biochem., 73, 1123-1128.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 4-hydroxyphenyl beta-D-xyloside
-
 Agaricus bisporus
1.14.18.1 4-hydroxyphenyl beta-xylodioside competitive inhibitor Agaricus bisporus
1.14.18.1 4-hydroxyphenyl beta-xylotetraoside competitive inhibitor, shows 35fold more potent inhibitory activity than beta-arbutin Agaricus bisporus
1.14.18.1 4-hydroxyphenyl beta-xylotrioside competitive inhibitor Agaricus bisporus
1.14.18.1 beta-arbutin i.e. 4-hydroxyphenyl beta-D-glucopyranoside Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-DOPA + O2
-
 Agaricus bisporus dopaquinone + H2O
-
 ?
1.14.18.1 L-tyrosine + O2
-
 Agaricus bisporus L-DOPA + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 tyrosinase
-
 Agaricus bisporus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.18.1 0.057
-
 4-hydroxyphenyl beta-xylotetraoside in 100 mM sodium phosphate buffer (pH 6.8), at 25°C Agaricus bisporus
1.14.18.1 0.2
-
 4-hydroxyphenyl beta-xylodioside in 100 mM sodium phosphate buffer (pH 6.8), at 25°C Agaricus bisporus
1.14.18.1 0.29
-
 4-hydroxyphenyl beta-xylotrioside in 100 mM sodium phosphate buffer (pH 6.8), at 25°C Agaricus bisporus
1.14.18.1 3.7
-
 4-hydroxyphenyl beta-D-xyloside in 100 mM sodium phosphate buffer (pH 6.8), at 25°C Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 0.18
-
 in 100 mM sodium phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 4-hydroxyphenyl beta-xylotetraoside
1.14.18.1 0.48
-
 in 100 mM sodium phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 4-hydroxyphenyl beta-xylotrioside
1.14.18.1 0.74
-
 in 100 mM sodium phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 4-hydroxyphenyl beta-xylodioside
1.14.18.1 3
-
 in 100 mM sodium phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 4-hydroxyphenyl beta-D-xyloside
1.14.18.1 6.3
-
-
 Agaricus bisporus beta-arbutin