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Literature summary extracted from

  • Weng, J.; Ma, J.; Fan, K.; Wang, W.
    Asymmetric conformational flexibility in the ATP-binding cassette transporter HI1470/1 (2009), Biophys. J., 96, 1918-1930.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
7.6.2.8 BtuCD-F complex, and HI470/1 X-ray diffraction structure analysis using PDB-IDs 2NQ2, 1L7V and 2QI9, overview Haemophilus influenzae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.8 membrane periplasmic orientation Haemophilus influenzae 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.8 ATP + H2O + vitamin B12/out Haemophilus influenzae
-
 ADP + phosphate + vitamin B12/in
-
 ?
7.6.2.8 additional information Haemophilus influenzae metal-chelate-type ABC transporter HI1470/1 is homologous with vitamin B12 importer BtuCD but exhibits a distinct inward-facing conformation in contrast to the outward-facing conformation of BtuCD. The outward-facing conformation of HI1470/1 is considered to be one of the intermediate states in the translocation cycle of BtuCD ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.8 Haemophilus influenzae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.8 ATP + H2O + vitamin B12/out
-
 Haemophilus influenzae ADP + phosphate + vitamin B12/in
-
 ?
7.6.2.8 additional information metal-chelate-type ABC transporter HI1470/1 is homologous with vitamin B12 importer BtuCD but exhibits a distinct inward-facing conformation in contrast to the outward-facing conformation of BtuCD. The outward-facing conformation of HI1470/1 is considered to be one of the intermediate states in the translocation cycle of BtuCD Haemophilus influenzae ?
-
 ?

Subunits

EC Number Subunits Comment Organism
7.6.2.8 dimer BtuCD structure analysis, overview Haemophilus influenzae
7.6.2.8 More HI1470/1 shows intrinsic asymmetric conformational flexibility. The metal-chelate-type ABC transporter HI1470/1 is homologous with vitamin B12 importer BtuCD but exhibits a distinct inward-facing conformation in contrast to the outward-facing conformation of BtuCD. The outward-facing conformation of HI1470/1 is considered to be one of the intermediate states in the translocation cycle of BtuCD Haemophilus influenzae

Synonyms

EC Number Synonyms Comment Organism
7.6.2.8 BtuCD
-
 Haemophilus influenzae
7.6.2.8 vitamin B12 importer
-
 Haemophilus influenzae

Cofactor

EC Number Cofactor Comment Organism Structure
7.6.2.8 ATP
-
 Haemophilus influenzae