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Literature summary extracted from

  • Freitas, R.F.; Prokopczyk, I.M.; Zottis, A.; Oliva, G.; Andricopulo, A.D.; Trevisan, M.T.; Vilegas, W.; Silva, M.G.; Montanari, C.A.
    Discovery of novel Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase inhibitors (2009), Bioorg. Med. Chem., 17, 2476-2482.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.12 (8E,11E)-C15:2-anacardic acid
-
 Trypanosoma cruzi
1.2.1.12 (8E,11E,14E)-C15:3-anacardic acid
-
 Trypanosoma cruzi
1.2.1.12 (E)-2-hydroxy-6-(pentadec-8-en-1-yl)benzoic acid
-
 Trypanosoma cruzi
1.2.1.12 guajaverin molecular docking studies. Guajaverin is stabilized by five hydrogen bonds with the amino acids Ser165, Thr226, Arg249, Ser134, and Glu336 Trypanosoma cruzi
1.2.1.12 mangiferin
-
 Trypanosoma cruzi
1.2.1.12 quercetin molecular docking studies. Quercetin is stabilized by two hydrogen bonds with the amino acids Ala198 and Pro253 Trypanosoma cruzi
1.2.1.12 tiliroside molecular docking studies. Tiliroside is stabilized by four hydrogen bonds with the amino acids Cys166, Ser134, and Ser110 Trypanosoma cruzi

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.12 Trypanosoma cruzi P22513
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.12 D-glyceraldehyde 3-phosphate + phosphate + NAD+
-
 Trypanosoma cruzi 3-phospho-D-glyceroyl phosphate + NADH
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.2.1.12 0.038
-
 pH 7.5, 25°C Trypanosoma cruzi (8E,11E,14E)-C15:3-anacardic acid
1.2.1.12 0.046
-
 pH 7.5, 25°C Trypanosoma cruzi tiliroside
1.2.1.12 0.069
-
 pH 7.5, 25°C Trypanosoma cruzi (8E,11E)-C15:2-anacardic acid
1.2.1.12 0.14
-
 pH 7.5, 25°C Trypanosoma cruzi guajaverin
1.2.1.12 0.142
-
 pH 7.5, 25°C Trypanosoma cruzi quercetin
1.2.1.12 0.149
-
 pH 7.5, 25°C Trypanosoma cruzi mangiferin
1.2.1.12 0.161
-
 pH 7.5, 25°C Trypanosoma cruzi (8E)-C15:1-anacardic acid