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Literature summary extracted from

  • Wang, Q.; Chen, M.; Zhu, H.; Zhang, J.; Fang, H.; Wang, B.; Xu, W.
    Design, synthesis, and QSAR studies of novel lysine derives as amino-peptidase N/CD13 inhibitors (2008), Bioorg. Med. Chem., 16, 5473-5481.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.2 actinonin
-
 Sus scrofa
3.4.11.2 AHPA-Val
-
 Sus scrofa
3.4.11.2 amastatin
-
 Sus scrofa
3.4.11.2 bestatin
-
 Sus scrofa
3.4.11.2 curcumin
-
 Sus scrofa
3.4.11.2 lapstatin
-
 Sus scrofa
3.4.11.2 leuhistin
-
 Sus scrofa
3.4.11.2 N6-[(benzyloxy)carbonyl]-N2-(2,4-dichlorobenzoyl)-L-lysine
-
 Sus scrofa
3.4.11.2 N6-[(benzyloxy)carbonyl]-N2-(2,4-dichlorobenzoyl)-N1-hydroxy-L-lysinamide
-
 Sus scrofa
3.4.11.2 N6-[(benzyloxy)carbonyl]-N2-(2-thienylcarbonyl)-L-lysine
-
 Sus scrofa
3.4.11.2 N6-[(benzyloxy)carbonyl]-N2-(2-thienylcarbonyl)-N1-hydroxy-L-lysinamide
-
 Sus scrofa
3.4.11.2 N6-[(benzyloxy)carbonyl]-N2-(3-nitrobenzoyl)-L-lysine
-
 Sus scrofa
3.4.11.2 N6-[(benzyloxy)carbonyl]-N2-(3-nitrobenzoyl)-N1-hydroxy-L-lysinamide
-
 Sus scrofa
3.4.11.2 N6-[(benzyloxy)carbonyl]-N2-(4-bromobenzoyl)-L-lysine
-
 Sus scrofa
3.4.11.2 N6-[(benzyloxy)carbonyl]-N2-(4-bromobenzoyl)-N1-hydroxy-L-lysinamide
-
 Sus scrofa
3.4.11.2 N6-[(benzyloxy)carbonyl]-N2-(4-nitrobenzoyl)-L-lysine
-
 Sus scrofa
3.4.11.2 N6-[(benzyloxy)carbonyl]-N2-(4-nitrobenzoyl)-N1-hydroxy-L-lysinamide
-
 Sus scrofa
3.4.11.2 N6-[(benzyloxy)carbonyl]-N2-(pyrazin-2-ylcarbonyl)-L-lysine
-
 Sus scrofa
3.4.11.2 N6-[(benzyloxy)carbonyl]-N2-(pyrazin-2-ylcarbonyl)-N1-hydroxy-L-lysinamide
-
 Sus scrofa
3.4.11.2 N6-[(benzyloxy)carbonyl]-N2-(pyridin-3-ylcarbonyl)-L-lysine
-
 Sus scrofa
3.4.11.2 N6-[(benzyloxy)carbonyl]-N2-(pyridin-3-ylcarbonyl)-N1-hydroxy-L-lysinamide
-
 Sus scrofa
3.4.11.2 N6-[(benzyloxy)carbonyl]-N2-2-furoyl-L-lysine
-
 Sus scrofa
3.4.11.2 N6-[(benzyloxy)carbonyl]-N2-2-furoyl-N1-hydroxy-L-lysinamide
-
 Sus scrofa
3.4.11.2 N6-[(benzyloxy)carbonyl]-N2-cinnamoyl-L-lysine
-
 Sus scrofa
3.4.11.2 N6-[(benzyloxy)carbonyl]-N2-cinnamoyl-N1-hydroxy-L-lysinamide
-
 Sus scrofa
3.4.11.2 N6-[(benzyloxy)carbonyl]-N2-isonicotinoyl-L-lysine
-
 Sus scrofa
3.4.11.2 N6-[(benzyloxy)carbonyl]-N2-isonicotinoyl-N1-hydroxy-L-lysinamide
-
 Sus scrofa
3.4.11.2 pasmmaplin A
-
 Sus scrofa
3.4.11.2 phebestin
-
 Sus scrofa
3.4.11.2 probestin
-
 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.2 microsome
-
 Sus scrofa
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.2 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.2 kidney
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.2 L-Leu-p-nitroanilide + H2O
-
 Sus scrofa L-Leu + p-nitroaniline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.2 amino-peptidase N
-
 Sus scrofa
3.4.11.2 APN
-
 Sus scrofa
3.4.11.2 CD13
-
 Sus scrofa

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.11.2 0.0132
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(2,4-dichlorobenzoyl)-N1-hydroxy-L-lysinamide
3.4.11.2 0.0155
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa bestatin
3.4.11.2 0.0912
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-isonicotinoyl-N1-hydroxy-L-lysinamide
3.4.11.2 0.0943
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(pyridin-3-ylcarbonyl)-N1-hydroxy-L-lysinamide
3.4.11.2 0.0958
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(3-nitrobenzoyl)-N1-hydroxy-L-lysinamide
3.4.11.2 0.097
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(pyrazin-2-ylcarbonyl)-N1-hydroxy-L-lysinamide
3.4.11.2 0.1079
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(4-nitrobenzoyl)-N1-hydroxy-L-lysinamide
3.4.11.2 0.108
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(3-nitrobenzoyl)-L-lysine
3.4.11.2 0.1119
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(4-bromobenzoyl)-N1-hydroxy-L-lysinamide
3.4.11.2 0.1272
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(2,4-dichlorobenzoyl)-L-lysine
3.4.11.2 0.1587
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-2-furoyl-N1-hydroxy-L-lysinamide
3.4.11.2 0.1591
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(2-thienylcarbonyl)-N1-hydroxy-L-lysinamide
3.4.11.2 0.1668
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(pyridin-3-ylcarbonyl)-L-lysine
3.4.11.2 0.188
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(4-bromobenzoyl)-L-lysine
3.4.11.2 0.1974
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(pyrazin-2-ylcarbonyl)-L-lysine
3.4.11.2 0.2022
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(4-nitrobenzoyl)-L-lysine
3.4.11.2 0.2151
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-cinnamoyl-L-lysine
3.4.11.2 0.2916
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-isonicotinoyl-L-lysine
3.4.11.2 0.5696
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-cinnamoyl-N1-hydroxy-L-lysinamide
3.4.11.2 1.121
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-2-furoyl-L-lysine
3.4.11.2 1.247
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(2-thienylcarbonyl)-L-lysine