EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.28 | (6R)-6-methyl-2-nitro-4,5,6,7-tetrahydrothieno[3,2-c]pyridine | - |
Homo sapiens | |
2.1.1.28 | (6R)-6-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carbonitrile | - |
Homo sapiens | |
2.1.1.28 | (6S)-6-methyl-2-nitro-4,5,6,7-tetrahydrothieno[3,2-c]pyridine | - |
Homo sapiens | |
2.1.1.28 | (6S)-6-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carbonitrile | - |
Homo sapiens | |
2.1.1.28 | 1,2,3,4-tetrahydroisoquinoline | - |
Homo sapiens | |
2.1.1.28 | 1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | - |
Homo sapiens | |
2.1.1.28 | 1-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)ethanone | - |
Homo sapiens | |
2.1.1.28 | 1-phenylmethanamine | - |
Homo sapiens | |
2.1.1.28 | 1-thiophen-2-ylmethanamine | - |
Homo sapiens | |
2.1.1.28 | 1-thiophen-3-ylmethanamine | - |
Homo sapiens | |
2.1.1.28 | 2-bromo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine | - |
Homo sapiens | |
2.1.1.28 | 2-bromo-6-(trifluoromethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine | - |
Homo sapiens | |
2.1.1.28 | 2-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine | - |
Homo sapiens | |
2.1.1.28 | 2-nitro-4,5,6,7-tetrahydrothieno[3,2-c]pyridine | - |
Homo sapiens | |
2.1.1.28 | 2-phenylethanamine | - |
Homo sapiens | |
2.1.1.28 | 2-Phenylethylamine | - |
Homo sapiens | |
2.1.1.28 | 2-thiophen-2-ylethanamine | - |
Homo sapiens | |
2.1.1.28 | 3-(trifluoromethyl)-1,2,3,4-tetrahydro[1]benzothieno[3,2-c]pyridine | - |
Homo sapiens | |
2.1.1.28 | 3-methyl-1,2,3,4-tetrahydroisoquinoline | - |
Homo sapiens | |
2.1.1.28 | 3-methyl-1,2,3,4-tetrahydro[1]benzothieno[3,2-c]pyridine | - |
Homo sapiens | |
2.1.1.28 | 3-methyl-7-nitro-1,2,3,4-tetrahydroisoquinoline | - |
Homo sapiens | |
2.1.1.28 | 3-Phenylpropylamine | - |
Homo sapiens | |
2.1.1.28 | 3-thienylmethylamine | inhibits the enzyme and is selective toward the alpha2-adrenoceptor | Homo sapiens | |
2.1.1.28 | 4,5,6,7-tetrahydrothieno[3,2-c]pyridine | - |
Homo sapiens | |
2.1.1.28 | 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carbonitrile | - |
Homo sapiens | |
2.1.1.28 | 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxamide | - |
Homo sapiens | |
2.1.1.28 | 6-(trifluoromethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine | - |
Homo sapiens | |
2.1.1.28 | 6-methyl-2-nitro-4,5,6,7-tetrahydrothieno[3,2-c]pyridine | - |
Homo sapiens | |
2.1.1.28 | 6-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine | - |
Homo sapiens | |
2.1.1.28 | 6-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carbonitrile | - |
Homo sapiens | |
2.1.1.28 | 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline | - |
Homo sapiens | |
2.1.1.28 | 7-bromo-1,2,3,4-tetrahydroisoquinoline | - |
Homo sapiens | |
2.1.1.28 | 7-bromo-3-methyl-1,2,3,4-tetrahydroisoquinoline | - |
Homo sapiens | |
2.1.1.28 | 7-nitro-1,2,3,4-tetrahydroisoquinoline | - |
Homo sapiens | |
2.1.1.28 | benzylamine | - |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.28 | S-adenosyl-L-methionine + norepinephrine | Homo sapiens | terminal step in epinephrine biosynthesis | S-adenosyl-L-homocysteine + epinephrine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.28 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.28 | S-adenosyl-L-methionine + norepinephrine | - |
Homo sapiens | S-adenosyl-L-homocysteine + epinephrine | - |
? | |
2.1.1.28 | S-adenosyl-L-methionine + norepinephrine | terminal step in epinephrine biosynthesis | Homo sapiens | S-adenosyl-L-homocysteine + epinephrine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.28 | PNMT | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.1.1.28 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.1.1.28 | 8 | - |
assay at | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.28 | S-adenosyl-L-methionine | - |
Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.1.28 | 0.0000031 | - |
7,8-dichloro-1,2,3,4-tetrahydroisoquinoline | pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.000017 | - |
7-bromo-3-methyl-1,2,3,4-tetrahydroisoquinoline | pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.000056 | - |
7-bromo-1,2,3,4-tetrahydroisoquinoline | pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.000067 | - |
3-methyl-1,2,3,4-tetrahydro[1]benzothieno[3,2-c]pyridine | pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.000072 | - |
3-methyl-7-nitro-1,2,3,4-tetrahydroisoquinoline | pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.00012 | - |
7-nitro-1,2,3,4-tetrahydroisoquinoline | pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.00028 | - |
1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.00031 | - |
(6S)-6-methyl-2-nitro-4,5,6,7-tetrahydrothieno[3,2-c]pyridine | S-isomer, pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.00073 | - |
2-bromo-6-(trifluoromethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine | pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.0012 | - |
2-bromo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine | pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.0014 | - |
3-methyl-1,2,3,4-tetrahydroisoquinoline | pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.0026 | - |
2-nitro-4,5,6,7-tetrahydrothieno[3,2-c]pyridine | pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.0033 | - |
(6S)-6-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carbonitrile | S-isomer, pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.0058 | - |
1,2,3,4-tetrahydroisoquinoline | pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.0058 | - |
6-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine | pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.0096 | - |
(6R)-6-methyl-2-nitro-4,5,6,7-tetrahydrothieno[3,2-c]pyridine | R-isomer, pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.015 | - |
4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carbonitrile | pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.017 | - |
3-(trifluoromethyl)-1,2,3,4-tetrahydro[1]benzothieno[3,2-c]pyridine | pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.021 | - |
2-bromo-6-(trifluoromethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine | pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.025 | - |
2-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine | pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.037 | - |
4,5,6,7-tetrahydrothieno[3,2-c]pyridine | pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.04 | - |
6-(trifluoromethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine | pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.061 | - |
1-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)ethanone | pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.1 | - |
4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxamide | pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.11 | - |
1-thiophen-3-ylmethanamine | pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.15 | - |
(6R)-6-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carbonitrile | R-isomer, pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.17 | - |
benzylamine | pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.22 | - |
2-Phenylethylamine | pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.3 | - |
2-thiophen-2-ylethanamine | pH 8.0, 37°C | Homo sapiens | |
2.1.1.28 | 0.45 | - |
1-thiophen-2-ylmethanamine | pH 8.0, 37°C | Homo sapiens |