EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
7.6.2.2 | cis-(Z)-flupentixol | is a non-competitive inhibitor that interacts with the substrate site but is not transported | Homo sapiens | |
7.6.2.2 | curcumin | modulates Pgp expression | Homo sapiens | |
7.6.2.2 | praeruptorin A | modulates Pgp expression | Homo sapiens | |
7.6.2.2 | XR9576 | is a non-competitive inhibitor that interacts with the substrate site but is not transported | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
7.6.2.2 | membrane | - |
Homo sapiens | 16020 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
7.6.2.2 | Mg2+ | - |
Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
7.6.2.2 | 170000 | - |
- |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.6.2.2 | ATP + H2O + xenobiotic/in | Homo sapiens | P-glycoprotein is a membrane ATP-driven drug exporter, Pgp actively extrudes a spectrum of hydrophobic xenobiotics, including a number of anticancer drugs | ADP + phosphate + xenobiotic/out | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
7.6.2.2 | Homo sapiens | - |
gene MDR1 encoding Pgp | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.6.2.2 | ATP + H2O + doxorubicin/in | - |
Homo sapiens | ADP + phosphate + doxorubicin/out | - |
? | |
7.6.2.2 | ATP + H2O + paclitaxel/in | - |
Homo sapiens | ADP + phosphate + paclitaxel/out | - |
? | |
7.6.2.2 | ATP + H2O + puromycin/in | - |
Homo sapiens | ADP + phosphate + puromycin/out | - |
? | |
7.6.2.2 | ATP + H2O + vinblastine/in | - |
Homo sapiens | ADP + phosphate + vinblastine/out | - |
? | |
7.6.2.2 | ATP + H2O + xenobiotic/in | structure-activity relationship, overview | Homo sapiens | ADP + phosphate + xenobiotic/out | - |
? | |
7.6.2.2 | ATP + H2O + xenobiotic/in | P-glycoprotein is a membrane ATP-driven drug exporter, Pgp actively extrudes a spectrum of hydrophobic xenobiotics, including a number of anticancer drugs | Homo sapiens | ADP + phosphate + xenobiotic/out | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
7.6.2.2 | P-glycoprotein | - |
Homo sapiens |
7.6.2.2 | Pgp | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
7.6.2.2 | ATP | - |
Homo sapiens |