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Literature summary extracted from

  • Grzywa, R.; Oleksyszyn, J.
    First synthesis of alpha-aminoalkyl-(N-substituted)thiocarbamoyl-phosphinates: inhibitors of aminopeptidase N (APN/CD13) with the new zinc-binding group (2008), Bioorg. Med. Chem. Lett., 18, 3734-3736.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.2 1-amino-2-methylpropyl(hexylcarbamothioyl)phosphinic acid
-
 Sus scrofa
3.4.11.2 1-amino-2-methylpropyl(isobutylcarbamothioyl)phosphinic acid
-
 Sus scrofa
3.4.11.2 1-amino-3-methylbutyl(hexylcarbamothioyl)phosphinic acid
-
 Sus scrofa
3.4.11.2 1-amino-3-methylbutyl(methylcarbamothioyl)phosphinic acid
-
 Sus scrofa
3.4.11.2 1-amino-3-phenylpropyl(4-methoxybenzylcarbamothioyl)phosphinic acid
-
 Sus scrofa
3.4.11.2 1-aminobutyl(4-methoxybenzylcarbamothioyl)phosphinic acid
-
 Sus scrofa
3.4.11.2 1-aminobutyl(phenethylcarbamothioyl)phosphinic acid
-
 Sus scrofa
3.4.11.2 1-aminoethyl(4-methoxybenzylcarbamothioyl)phosphinic acid
-
 Sus scrofa
3.4.11.2 1-aminoethyl(phenethylcarbamothioyl)phosphinic acid
-
 Sus scrofa
3.4.11.2 1-aminohexyl(4-methoxyphenethylcarbamothioyl)phosphinic acid
-
 Sus scrofa
3.4.11.2 1-aminohexyl(phenethylcarbamothioyl)phosphinic acid
-
 Sus scrofa
3.4.11.2 bestatin
-
 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.2 membrane
-
 Sus scrofa 16020
-
3.4.11.2 microsome
-
 Sus scrofa
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.2 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.2 kidney
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.2 L-Leu-7-amido-4-methylcoumarin + H2O
-
 Sus scrofa L-Leu + 7-amino-4-methylcoumarin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.2 aminopeptidase N
-
 Sus scrofa
3.4.11.2 AP-N
-
 Sus scrofa
3.4.11.2 CD13
-
 Sus scrofa

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.11.2 0.00025
-
 in sodium phosphate buffer (pH 7.2), at 25°C Sus scrofa 1-aminohexyl(4-methoxyphenethylcarbamothioyl)phosphinic acid
3.4.11.2 0.00038
-
 in sodium phosphate buffer (pH 7.2), at 25°C Sus scrofa 1-amino-3-phenylpropyl(4-methoxybenzylcarbamothioyl)phosphinic acid
3.4.11.2 0.0005
-
 in sodium phosphate buffer (pH 7.2), at 25°C Sus scrofa 1-amino-3-methylbutyl(hexylcarbamothioyl)phosphinic acid
3.4.11.2 0.00068
-
 in sodium phosphate buffer (pH 7.2), at 25°C Sus scrofa 1-aminobutyl(4-methoxybenzylcarbamothioyl)phosphinic acid
3.4.11.2 0.00073
-
 in sodium phosphate buffer (pH 7.2), at 25°C Sus scrofa 1-aminohexyl(phenethylcarbamothioyl)phosphinic acid
3.4.11.2 0.00112
-
 in sodium phosphate buffer (pH 7.2), at 25°C Sus scrofa 1-aminoethyl(4-methoxybenzylcarbamothioyl)phosphinic acid
3.4.11.2 0.00118
-
 in sodium phosphate buffer (pH 7.2), at 25°C Sus scrofa 1-amino-2-methylpropyl(hexylcarbamothioyl)phosphinic acid
3.4.11.2 0.0019
-
 in sodium phosphate buffer (pH 7.2), at 25°C Sus scrofa 1-amino-2-methylpropyl(isobutylcarbamothioyl)phosphinic acid
3.4.11.2 0.0021
-
 in sodium phosphate buffer (pH 7.2), at 25°C Sus scrofa bestatin
3.4.11.2 0.00228
-
 in sodium phosphate buffer (pH 7.2), at 25°C Sus scrofa 1-aminobutyl(phenethylcarbamothioyl)phosphinic acid
3.4.11.2 0.0042
-
 in sodium phosphate buffer (pH 7.2), at 25°C Sus scrofa 1-aminoethyl(phenethylcarbamothioyl)phosphinic acid
3.4.11.2 0.01056
-
 in sodium phosphate buffer (pH 7.2), at 25°C Sus scrofa 1-amino-3-methylbutyl(methylcarbamothioyl)phosphinic acid