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Literature summary extracted from

  • Smagur, J.; Guzik, K.; Bzowska, M.; Kuzak, M.; Zarebski, M.; Kantyka, T.; Walski, M.; Gajkowska, B.; Potempa, J.
    Staphylococcal cysteine protease staphopain B (SspB) induces rapid engulfment of human neutrophils and monocytes by macrophages (2009), Biol. Chem., 390, 361-371.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.48 additional information immunglobulin G and immunglobulin G's Fc fragment reduce the effect of SspB Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.48 Staphylococcus aureus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.22.48 additional information
-
peripheral blood neutrophils and monocytes exposed to SspB are extensively phagocytosed by resting human monocyte-derived macrophages in a time- and concentration-dependent manner. SspB-treated neutrophils engulfed in phagosomesstill preserve mitochondrial potential. SspB blocks phagocytosis of opsonised Staphylococcus aureus by neutrophils and monocytes. SspB blocks the chemotactic activity of neutrophils. SspB decreases surface expression of the major repulsion signal CD31 on neutrophils both in the absence and presence of human serum. Staphylococcus aureus

Synonyms

EC Number Synonyms Comment Organism
3.4.22.48 SspB
-
Staphylococcus aureus
3.4.22.48 staphopain B
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Staphylococcus aureus