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Literature summary extracted from

  • Sun, X.; Wiesner, B.; Lorenz, D.; Papsdorf, G.; Pankow, K.; Wang, P.; Dietrich, N.; Siems, W.E.; Maul, B.
    Interaction of angiotensin-converting enzyme (ACE) with membrane-bound carboxypeptidase M (CPM) - a new function of ACE (2008), Biol. Chem., 389, 1477-1485.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.17.12 additional information there is a spatial proximity and interaction between angiotensin-converting enzyme and endogenous carboxypeptidase M in CHO cells, as well as a weak but detectable release of glycosylphosphatidylinositol-anchored carboxypeptidase M evoked by co-localized between angiotensin-converting enzyme Cricetulus griseus
3.4.17.12 additional information there is a spatial proximity and interaction between angiotensin-converting enzyme and endogenous carboxypeptidase M in MDCK cells, as well as a weak but detectable release of glycosylphosphatidylinositol-anchored carboxypeptidase M evoked by co-localized between angiotensin-converting enzyme Canis lupus familiaris

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.12 (2-guanidinoethylmercapto)succinic acid
-
 Canis lupus familiaris
3.4.17.12 (2-guanidinoethylmercapto)succinic acid
-
 Cricetulus griseus
3.4.17.12 DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid specific carboxypeptidase M inhibitor Canis lupus familiaris
3.4.17.12 DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid specific carboxypeptidase M inhibitor Cricetulus griseus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.17.12 membrane
-
 Cricetulus griseus 16020
-
3.4.17.12 membrane
-
 Canis lupus familiaris 16020
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.12 Canis lupus familiaris
-
-
-
3.4.17.12 Cricetulus griseus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.17.12 glycoprotein
-
 Cricetulus griseus
3.4.17.12 glycoprotein
-
 Canis lupus familiaris

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.12 CHO cell
-
 Cricetulus griseus
-
3.4.17.12 Madin-Darby canine kidney cell
-
 Canis lupus familiaris
-
3.4.17.12 MDCK cell
-
 Canis lupus familiaris
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.12 dansyl-L-Ala-L-Arg + H2O
-
 Cricetulus griseus dansyl-L-Ala + L-Arg
-
 ?
3.4.17.12 dansyl-L-Ala-L-Arg + H2O
-
 Canis lupus familiaris dansyl-L-Ala + L-Arg
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.12 CPM
-
 Cricetulus griseus
3.4.17.12 CPM
-
 Canis lupus familiaris