EC Number | Cloned (Comment) | Organism |
---|---|---|
7.6.2.2 | gene dMRP/CG6214, expression in Spodoptera frugiperda Sf9 cells | Drosophila melanogaster |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
7.6.2.2 | benzbromarone | - |
Drosophila melanogaster | |
7.6.2.2 | indomethacin | - |
Drosophila melanogaster | |
7.6.2.2 | MK571 | the leukotriene receptor antagonist | Drosophila melanogaster | |
7.6.2.2 | additional information | the enzyme is inhibited by the transported substrates | Drosophila melanogaster | |
7.6.2.2 | probenecid | - |
Drosophila melanogaster |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
7.6.2.2 | additional information | - |
additional information | kinetics and substrate specificities, overview | Drosophila melanogaster | |
7.6.2.2 | 0.231 | - |
leukotriene C4/in | pH 7.0, 37°C | Drosophila melanogaster | |
7.6.2.2 | 0.344 | - |
beta-estradiol 17-beta-D-glucuronide/in | pH 7.0, 37°C | Drosophila melanogaster |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
7.6.2.2 | membrane | - |
Drosophila melanogaster | 16020 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
7.6.2.2 | Mg2+ | dependent on | Drosophila melanogaster |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.6.2.2 | ATP + H2O + xenobiotic/in | Drosophila melanogaster | - |
ADP + phosphate + xenobiotic/out | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
7.6.2.2 | Drosophila melanogaster | - |
gene dMRP/CG6214 | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
7.6.2.2 | additional information | - |
substrate specificity, overview | Drosophila melanogaster |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.6.2.2 | ATP + H2O + beta-estradiol 17-beta-D-glucuronide/in | - |
Drosophila melanogaster | ADP + phosphate + beta-estradiol 17-beta-D-glucuronide/out | - |
? | |
7.6.2.2 | ATP + H2O + calcein/in | - |
Drosophila melanogaster | ADP + phosphate + calcein/out | - |
? | |
7.6.2.2 | ATP + H2O + carboxydichlorofluorescein/in | - |
Drosophila melanogaster | ADP + phosphate + carboxydichlorofluorescein/out | - |
? | |
7.6.2.2 | ATP + H2O + leukotriene C4/in | high activity with | Drosophila melanogaster | ADP + phosphate + leukotriene C4/out | - |
? | |
7.6.2.2 | ATP + H2O + xenobiotic/in | - |
Drosophila melanogaster | ADP + phosphate + xenobiotic/out | - |
? | |
7.6.2.2 | additional information | the fly enzyme exhibits a unique high level basal ATPase activity that is inhibited by the transported substrates, and it is capable of transporting several human MRP substrates like beta-estradiol 17-beta-D-glucuronide, leukotriene C4, calcein, fluo3 and carboxydichlorofluorescein | Drosophila melanogaster | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
7.6.2.2 | DMRP | - |
Drosophila melanogaster |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
7.6.2.2 | 37 | - |
assay at | Drosophila melanogaster |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
7.6.2.2 | 7 | - |
assay at | Drosophila melanogaster |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
7.6.2.2 | ATP | dependent on | Drosophila melanogaster |