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Literature summary extracted from

  • Szeri, F.; Ilias, A.; Pomozi, V.; Robinow, S.; Bakos, E.; Varadi, A.
    The high turnover Drosophila multidrug resistance-associated protein shares the biochemical features of its human orthologues (2009), Biochim. Biophys. Acta, 1788, 402-409.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.6.2.2 gene dMRP/CG6214, expression in Spodoptera frugiperda Sf9 cells Drosophila melanogaster

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.6.2.2 benzbromarone
-
Drosophila melanogaster
7.6.2.2 indomethacin
-
Drosophila melanogaster
7.6.2.2 MK571 the leukotriene receptor antagonist Drosophila melanogaster
7.6.2.2 additional information the enzyme is inhibited by the transported substrates Drosophila melanogaster
7.6.2.2 probenecid
-
Drosophila melanogaster

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
7.6.2.2 additional information
-
additional information kinetics and substrate specificities, overview Drosophila melanogaster
7.6.2.2 0.231
-
leukotriene C4/in pH 7.0, 37°C Drosophila melanogaster
7.6.2.2 0.344
-
beta-estradiol 17-beta-D-glucuronide/in pH 7.0, 37°C Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.2 membrane
-
Drosophila melanogaster 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.6.2.2 Mg2+ dependent on Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.2 ATP + H2O + xenobiotic/in Drosophila melanogaster
-
ADP + phosphate + xenobiotic/out
-
?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.2 Drosophila melanogaster
-
gene dMRP/CG6214
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7.6.2.2 additional information
-
substrate specificity, overview Drosophila melanogaster

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.2 ATP + H2O + beta-estradiol 17-beta-D-glucuronide/in
-
Drosophila melanogaster ADP + phosphate + beta-estradiol 17-beta-D-glucuronide/out
-
?
7.6.2.2 ATP + H2O + calcein/in
-
Drosophila melanogaster ADP + phosphate + calcein/out
-
?
7.6.2.2 ATP + H2O + carboxydichlorofluorescein/in
-
Drosophila melanogaster ADP + phosphate + carboxydichlorofluorescein/out
-
?
7.6.2.2 ATP + H2O + leukotriene C4/in high activity with Drosophila melanogaster ADP + phosphate + leukotriene C4/out
-
?
7.6.2.2 ATP + H2O + xenobiotic/in
-
Drosophila melanogaster ADP + phosphate + xenobiotic/out
-
?
7.6.2.2 additional information the fly enzyme exhibits a unique high level basal ATPase activity that is inhibited by the transported substrates, and it is capable of transporting several human MRP substrates like beta-estradiol 17-beta-D-glucuronide, leukotriene C4, calcein, fluo3 and carboxydichlorofluorescein Drosophila melanogaster ?
-
?

Synonyms

EC Number Synonyms Comment Organism
7.6.2.2 DMRP
-
Drosophila melanogaster

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
7.6.2.2 37
-
assay at Drosophila melanogaster

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6.2.2 7
-
assay at Drosophila melanogaster

Cofactor

EC Number Cofactor Comment Organism Structure
7.6.2.2 ATP dependent on Drosophila melanogaster