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Literature summary extracted from

  • Mao, C.; Obeid, L.M.
    Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate (2008), Biochim. Biophys. Acta, 1781, 424-434.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.1.23
-
 Homo sapiens
3.5.1.23
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.23 endoplasmic reticulum
-
 Homo sapiens 5783
-
3.5.1.23 Golgi apparatus
-
 Homo sapiens 5794
-
3.5.1.23 lysosome
-
 Homo sapiens 5764
-
3.5.1.23 plasma membrane
-
 Homo sapiens 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.1.23 Ca2+
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.1.23 13000
-
 processed mature heterodimeric enzyme, alpha subunit Homo sapiens
3.5.1.23 28000
-
 apparent molecular weight, deglycosylated beta subunit Homo sapiens
3.5.1.23 31000
-
 SDS-PAGE and Western blot analysis Homo sapiens
3.5.1.23 31300
-
 theoretical value, Western blot analysis shows a molecular mass close to the predicted one Homo sapiens
3.5.1.23 31600
-
 theoretical value, Western blot analysis shows a molecular mass close to the predicted one Homo sapiens
3.5.1.23 40000
-
 processed mature heterodimeric enzyme, beta subunit Homo sapiens
3.5.1.23 54000
-
 synthesized as a polypeptide of 395 amino acids, 53 - 55 kDa Homo sapiens
3.5.1.23 95000
-
 glycosylated protein Mus musculus
3.5.1.23 118000
-
 isoform 2 Homo sapiens
3.5.1.23 142000
-
 isoform 1 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.23 ceramide + H2O Homo sapiens
-
 sphingosine + fatty acid
-
 ?
3.5.1.23 ceramide + H2O Mus musculus
-
 sphingosine + fatty acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.23 Homo sapiens
-
-
-
3.5.1.23 Homo sapiens Q5QJU3
-
-
3.5.1.23 Homo sapiens Q8TDN7
-
-
3.5.1.23 Homo sapiens Q9NR71
-
-
3.5.1.23 Homo sapiens Q9NUN7
-
-
3.5.1.23 Mus musculus Q8R4X1
-
-
3.5.1.23 Mus musculus Q8VD53
-
-
3.5.1.23 Mus musculus Q9D099
-
-
3.5.1.23 Mus musculus Q9JHE3
-
-
3.5.1.23 Mus musculus Q9WV54
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.5.1.23 glycoprotein
-
 Homo sapiens
3.5.1.23 glycoprotein
-
 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.23 skin
-
 Mus musculus
-
3.5.1.23 skin
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.23 ceramide + H2O
-
 Homo sapiens sphingosine + fatty acid
-
 ?
3.5.1.23 ceramide + H2O
-
 Mus musculus sphingosine + fatty acid
-
 ?

Subunits

EC Number Subunits Comment Organism
3.5.1.23 heterodimer
-
 Homo sapiens
3.5.1.23 heterodimer alpha and beta subunit Mus musculus

Synonyms

EC Number Synonyms Comment Organism
3.5.1.23 acid ceramidase
-
 Homo sapiens
3.5.1.23 acid ceramidase
-
 Mus musculus
3.5.1.23 alkaline ceramidase 1 ACER1 Mus musculus
3.5.1.23 alkaline ceramidase 1 ACER1 Homo sapiens
3.5.1.23 alkaline ceramidase 2 ACER2 Homo sapiens
3.5.1.23 alkaline ceramidase 2 ACER2 Mus musculus
3.5.1.23 alkaline ceramidase 3 ACER3 Homo sapiens
3.5.1.23 alkaline ceramidase 3 ACER3 Mus musculus
3.5.1.23 ceramidase
-
 Homo sapiens
3.5.1.23 ceramidase
-
 Mus musculus
3.5.1.23 neutral ceramidase
-
 Homo sapiens
3.5.1.23 neutral ceramidase
-
 Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.23 4.5
-
-
 Homo sapiens
3.5.1.23 7
-
-
 Homo sapiens
3.5.1.23 8.5
-
-
 Homo sapiens
3.5.1.23 9
-
-
 Homo sapiens
3.5.1.23 9.5
-
-
 Homo sapiens