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Literature summary extracted from

  • Euro, L.; Belevich, G.; Verkhovsky, M.I.; Wikstroem, M.; Verkhovskaya, M.
    Conserved lysine residues of the membrane subunit NuoM are involved in energy conversion by the proton-pumping NADH:ubiquinone oxidoreductase (Complex I) (2008), Biochim. Biophys. Acta, 1777, 1166-1172.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
7.1.1.2 E144A mutation in subunit NuoM, quinone reductase activity is lost Escherichia coli
7.1.1.2 E144D mutation in subunit NuoM, mutant has wild type sensitivity to rolliniastatin and complete proton-pumping efficiency of complex I Escherichia coli
7.1.1.2 E144D mutation in subunit NuoM, quinone reductase activity is unchanged Escherichia coli
7.1.1.2 K234A mutation in subunit NuoM, quinone reductase activity is lost Escherichia coli
7.1.1.2 K234R mutation in subunit NuoM, quinone reductase activity is lost Escherichia coli
7.1.1.2 K265A mutation in subunit NuoM, mutant has wild type sensitivity to rolliniastatin and complete proton-pumping efficiency of complex I Escherichia coli
7.1.1.2 K265A mutation in subunit NuoM, quinone reductase activity is decreased Escherichia coli
7.1.1.2 W243A mutation in subunit NuoM, mutant has wild type sensitivity to rolliniastatin and complete proton-pumping efficiency of complex I Escherichia coli
7.1.1.2 W243A mutation in subunit NuoM, quinone reductase activity is decreased Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.2 rolliniastatin
-
 Escherichia coli

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.2 membrane conserved lysine residues of the membrane subunit NuoM are involved in energy conversion by the proton-pumping NADH:ubiquinone oxidoreductase Escherichia coli 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.1.1.2 NADH + H+ + ubiquinone Escherichia coli conserved lysine residues of the membrane subunit NuoM are involved in energy conversion by the proton-pumping NADH:ubiquinone oxidoreductase NAD+ + ubiquinol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.2 NADH + H+ + decylubiquinone
-
 Escherichia coli NAD+ + decylubiquinol
-
 ?
7.1.1.2 NADH + H+ + ubiquinone conserved lysine residues of the membrane subunit NuoM are involved in energy conversion by the proton-pumping NADH:ubiquinone oxidoreductase Escherichia coli NAD+ + ubiquinol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.2 complex I
-
 Escherichia coli
7.1.1.2 proton-pumping NADH:ubiquinone oxidoreductase
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
7.1.1.2 NADH
-
 Escherichia coli