EC Number | Cloned (Comment) | Organism |
---|---|---|
1.3.5.2 | - |
Homo sapiens |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
1.3.5.2 | in complex with inhibitors 6-chloro-2-(2'-fluorobiphenyl-4-yl)quinoline-4-carboxylic acid and and without any bound inhibitor, to 2.3 A, 2.1 A, and 3.0 A resolution, respectively. Inhibitor 5-methoxy-2-[(4-phenoxyphenyl)amino]benzoic acid 5-methoxy-2-[(4-phenoxyphenyl)amino]benzoic acid interacts with residue Y356. Loop region of residues L68-R72 may interfere with inhibitor/cofactor binding. Loop region N212-L224 may be important for the enzymatic reaction | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.3.5.2 | 5-methoxy-2-[(4-phenoxyphenyl)amino]benzoic acid | - |
Homo sapiens | |
1.3.5.2 | 6-chloro-2-(2'-fluorobiphenyl-4-yl)quinoline-4-carboxylic acid | - |
Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.3.5.2 | Homo sapiens | Q02127 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.5.2 | (S)-dihydroorotate + 2,6-dichlorophenolindophenol | - |
Homo sapiens | orotate + reduced 2,6-dichlorophenolindophenol | - |
? |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.3.5.2 | 0.000015 | - |
pH 8.0, 22°C | Homo sapiens | 6-chloro-2-(2'-fluorobiphenyl-4-yl)quinoline-4-carboxylic acid | |
1.3.5.2 | 0.000081 | - |
pH 8.0, 22°C | Homo sapiens | 5-methoxy-2-[(4-phenoxyphenyl)amino]benzoic acid |