Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Rafice, S.A.; Chauhan, N.; Efimov, I.; Basran, J.; Raven, E.L.
    Oxidation of L-tryptophan in biology: a comparison between tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase (2009), Biochem. Soc. Trans., 37, 408-412.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.52 C-terminal hexahistidine tag, expressed in Escherichia coli Homo sapiens
1.13.11.52 expressed in Escherichia coli Homo sapiens
1.13.11.52 expressed in Escherichia coli Xanthomonas campestris
1.13.11.52 expressed in Escherichia coli Cupriavidus metallidurans

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.13.11.52
-
 Homo sapiens
1.13.11.52
-
 Xanthomonas campestris
1.13.11.52
-
 Cupriavidus metallidurans

Protein Variants

EC Number Protein Variants Comment Organism
1.13.11.52 S167H active site, mimic tryptophan 2,3-oxigenase Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.52 0.01
-
 L-tryptophan
-
 Homo sapiens
1.13.11.52 0.114
-
 L-tryptophan
-
 Xanthomonas campestris
1.13.11.52 0.222
-
 L-tryptophan
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.13.11.52 120000
-
 about 120000 Da in prokaryotes Xanthomonas campestris
1.13.11.52 120000
-
 about 120000 Da in prokaryotes Cupriavidus metallidurans
1.13.11.52 190000
-
 about 190000 Da in eukaryotes Drosophila melanogaster
1.13.11.52 190000
-
 about 190000 Da in eukaryotes Homo sapiens
1.13.11.52 190000
-
 about 190000 Da in eukaryotes Saccharomyces cerevisiae
1.13.11.52 190000
-
 about 190000 Da in eukaryotes Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.52 Cupriavidus metallidurans
-
-
-
1.13.11.52 Drosophila melanogaster
-
-
-
1.13.11.52 Homo sapiens
-
-
-
1.13.11.52 Mus musculus
-
-
-
1.13.11.52 Oryctolagus cuniculus
-
-
-
1.13.11.52 Saccharomyces cerevisiae
-
-
-
1.13.11.52 Xanthomonas campestris
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.52 5-fluorotryptophan + O2
-
 Homo sapiens ?
-
 ?
1.13.11.52 5-hydroxytryptamine + O2
-
 Homo sapiens ?
-
 ?
1.13.11.52 5-hydroxytryptophan + O2
-
 Homo sapiens ?
-
 ?
1.13.11.52 5-methyltryptophan + O2
-
 Homo sapiens ?
-
 ?
1.13.11.52 6-fluorotryptophan + O2
-
 Homo sapiens ?
-
 ?
1.13.11.52 D-tryptophan + O2
-
 Homo sapiens ?
-
 ?
1.13.11.52 L-tryptophan + O2
-
 Homo sapiens N-formyl-L-kynurenine
-
 ?
1.13.11.52 L-tryptophan + O2
-
 Drosophila melanogaster N-formylkynurenine
-
 ?
1.13.11.52 L-tryptophan + O2
-
 Mus musculus N-formylkynurenine
-
 ?
1.13.11.52 L-tryptophan + O2
-
 Homo sapiens N-formylkynurenine
-
 ?
1.13.11.52 L-tryptophan + O2
-
 Saccharomyces cerevisiae N-formylkynurenine
-
 ?
1.13.11.52 L-tryptophan + O2
-
 Oryctolagus cuniculus N-formylkynurenine
-
 ?
1.13.11.52 L-tryptophan + O2
-
 Xanthomonas campestris N-formylkynurenine
-
 ?
1.13.11.52 L-tryptophan + O2
-
 Cupriavidus metallidurans N-formylkynurenine
-
 ?
1.13.11.52 tryptamine + O2
-
 Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.13.11.52 monomer about 45000 Da Homo sapiens
1.13.11.52 tetramer
-
 Drosophila melanogaster
1.13.11.52 tetramer
-
 Mus musculus
1.13.11.52 tetramer
-
 Homo sapiens
1.13.11.52 tetramer
-
 Saccharomyces cerevisiae
1.13.11.52 tetramer
-
 Oryctolagus cuniculus
1.13.11.52 tetramer
-
 Xanthomonas campestris
1.13.11.52 tetramer
-
 Cupriavidus metallidurans

Synonyms

EC Number Synonyms Comment Organism
1.13.11.52 indoleamine 2,3-dioxygenase
-
 Homo sapiens
1.13.11.52 tryptophan 2,3-dioxygenase
-
 Drosophila melanogaster
1.13.11.52 tryptophan 2,3-dioxygenase
-
 Mus musculus
1.13.11.52 tryptophan 2,3-dioxygenase
-
 Homo sapiens
1.13.11.52 tryptophan 2,3-dioxygenase
-
 Saccharomyces cerevisiae
1.13.11.52 tryptophan 2,3-dioxygenase
-
 Oryctolagus cuniculus
1.13.11.52 tryptophan 2,3-dioxygenase
-
 Xanthomonas campestris
1.13.11.52 tryptophan 2,3-dioxygenase
-
 Cupriavidus metallidurans

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.13.11.52 1.4
-
 L-tryptophan
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.13.11.52 heme
-
 Drosophila melanogaster
1.13.11.52 heme
-
 Mus musculus
1.13.11.52 heme
-
 Homo sapiens
1.13.11.52 heme
-
 Saccharomyces cerevisiae
1.13.11.52 heme
-
 Oryctolagus cuniculus
1.13.11.52 heme
-
 Xanthomonas campestris
1.13.11.52 heme
-
 Cupriavidus metallidurans