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Literature summary extracted from

  • Williams, M.
    Commentary: genome-based CNS drug discovery: D-amino acid oxidase (DAAO) as a novel target for antipsychotic medications: progress and challenges (2009), Biochem. Pharmacol., 78, 1360-1365.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.4.3.3 pLG72 i.e. DAOA or D-amino acid oxidase activator, interacts with and activates the enzyme Rattus norvegicus
1.4.3.3 pLG72 i.e. DAOA or D-amino acid oxidase activator, interacts with and activates the enzyme, genotyping in healthy persons and schizophrenia patients, overview Homo sapiens

Application

EC Number Application Comment Organism
1.4.3.3 drug development the enzyme is a drug target in schizophrenia Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.3 4H-thieno[3,2-b] pyrrole-5-carboxylic acid i.e. compound 8, very specific inhibitor of DAAO Homo sapiens
1.4.3.3 4H-thieno[3,2-b] pyrrole-5-carboxylic acid i.e. compound 8, very specific inhibitor of DAAO. Compound 8 at 200 mg/kg body weight inhibits rat kidney and cerebellar DAAO by approximately 96% and 80%, respectively. Effects after in vivo application, overview Rattus norvegicus
1.4.3.3 5-methylpyrazole-3-carboxylic acid i.e. AS057278 Homo sapiens
1.4.3.3 5-methylpyrazole-3-carboxylic acid i.e. AS057278 Rattus norvegicus
1.4.3.3 6-chlorobenzo[d]isoxazol-3-ol competitive Homo sapiens
1.4.3.3 6-chlorobenzo[d]isoxazol-3-ol competitive Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.3 D-alanine + H2O + O2 Homo sapiens
-
 pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-alanine + H2O + O2 Rattus norvegicus
-
 pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-serine + H2O + O2 Homo sapiens
-
 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
1.4.3.3 D-serine + H2O + O2 Rattus norvegicus
-
 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.3 Homo sapiens
-
-
-
1.4.3.3 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.3 brain
-
 Homo sapiens
-
1.4.3.3 brain
-
 Rattus norvegicus
-
1.4.3.3 cerebellum
-
 Rattus norvegicus
-
1.4.3.3 kidney
-
 Homo sapiens
-
1.4.3.3 kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.3 D-alanine + H2O + O2
-
 Homo sapiens pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-alanine + H2O + O2
-
 Rattus norvegicus pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-serine + H2O + O2
-
 Homo sapiens 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
1.4.3.3 D-serine + H2O + O2
-
 Rattus norvegicus 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.3 D-amino acid oxidase
-
 Homo sapiens
1.4.3.3 D-amino acid oxidase
-
 Rattus norvegicus
1.4.3.3 DAAO
-
 Homo sapiens
1.4.3.3 DAAO
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.4.3.3 0.000145
-
-
 Homo sapiens 4H-thieno[3,2-b] pyrrole-5-carboxylic acid
1.4.3.3 0.000145
-
-
 Rattus norvegicus 4H-thieno[3,2-b] pyrrole-5-carboxylic acid
1.4.3.3 0.000188
-
-
 Homo sapiens 6-chlorobenzo[d]isoxazol-3-ol
1.4.3.3 0.000188
-
-
 Rattus norvegicus 6-chlorobenzo[d]isoxazol-3-ol
1.4.3.3 0.000901
-
-
 Homo sapiens 5-methylpyrazole-3-carboxylic acid
1.4.3.3 0.000901
-
-
 Rattus norvegicus 5-methylpyrazole-3-carboxylic acid