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Literature summary extracted from

  • Aleksandrov, L.; Aleksandrov, A.; Riordan, J.R.
    Mg2+-dependent ATP occlusion at the first nucleotide-binding domain (NBD1) of CFTR does not require the second (NBD2) (2008), Biochem. J., 416, 129-136.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.6.1.6 stable expression of wild-type and mutant DELTANBD2 CFTR in BHK-21 cell membranes Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
5.6.1.6 additional information construction of truncation mutant DELTANBD2 CFTR terminating at residue 1172 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.1.6 8-azido-ATP is retained at nucleotide-binding domain 1, NBD1 at low temperature even in the absence of bivalent cations Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.6.1.6 membrane
-
 Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.6.1.6 Mg2+ dependent on Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.6 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.1.6 ATP + H2O + closed Cl- channel Mg2+-dependent ATP occlusion at the first nucleotide-binding domain, NBD1, of CFTR does not require the second, NBD2. ATP binding to the first and second NBDs of CFTR are bivalent-cation-independent and -dependent steps, respectively Homo sapiens ADP + phosphate + open Cl- channel
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.1.6 CFTR
-
 Homo sapiens
5.6.1.6 cystic fibrosis transmembrane conductance regulator
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
5.6.1.6 37
-
 assay at Homo sapiens