EC Number | Cloned (Comment) | Organism |
---|---|---|
1.10.5.1 | - |
Homo sapiens |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
1.10.5.1 | the crystal structure of melatonin and 2-iodomelatonin in complex with quinone reductase 2 provide a detailed description of the enzyme active site that can now be utilized in the design of new and potent inhibitors of the enzyme, hanging-drop vapour-diffusion method | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.10.5.1 | 2-iodomelatonin | - |
Homo sapiens | |
1.10.5.1 | 5-hydroxytryptamine | - |
Homo sapiens | |
1.10.5.1 | Melatonin | competitive inhibitor against N-methyldihydronicotinamide, uncompetitive against menadione. Melatonin and its analogues bind to and inhibit QR2 within the active site and not at an allosteric site | Homo sapiens | |
1.10.5.1 | N-acetyl-5-hydroxytryptamine | - |
Homo sapiens | |
1.10.5.1 | resveratrol | - |
Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.10.5.1 | cytosol | - |
Homo sapiens | 5829 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.10.5.1 | Homo sapiens | P16083 | recombinant | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.10.5.1 | - |
Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.10.5.1 | N-methyldihydronicotinamide + menadione | - |
Homo sapiens | N-methylnicotinamide + menadiol | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.10.5.1 | MT3 | - |
Homo sapiens |
1.10.5.1 | QR2 | - |
Homo sapiens |
1.10.5.1 | quinone reductase 2 | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.10.5.1 | 25 | - |
- |
Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.10.5.1 | 8 | - |
- |
Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.10.5.1 | 0.0072 | - |
Melatonin | pH 8, 25°C, competitive inhibitor against N-methyldihydronicotinamide | Homo sapiens | |
1.10.5.1 | 0.092 | - |
Melatonin | pH 8, 25°C, uncompetitive against menadione | Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.10.5.1 | 0.00096 | - |
pH 8, 25°C | Homo sapiens | resveratrol | |
1.10.5.1 | 0.0011 | - |
pH 8, 25°C | Homo sapiens | 2-iodomelatonin | |
1.10.5.1 | 0.0099 | - |
pH 8, 25°C | Homo sapiens | N-acetyl-5-hydroxytryptamine | |
1.10.5.1 | 0.0113 | - |
pH 8, 25°C | Homo sapiens | Melatonin | |
1.10.5.1 | 0.0539 | - |
pH 8, 25°C | Homo sapiens | 5-hydroxytryptamine |