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Literature summary extracted from

  • Ishimura, A.; Terashima, M.; Kimura, H.; Akagi, K.; Suzuki, Y.; Sugano, S.; Suzuki, T.
    Jmjd2c histone demethylase enhances the expression of Mdm2 oncogene (2009), Biochem. Biophys. Res. Commun., 389, 366-371.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.11.65 expression of FLAG-tagged wild-type and H190A mutant Jmjd2c in mouse embryonic fibroblasts Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
1.14.11.65 H190A inactive mutant Mus musculus
1.14.11.65 additional information overexpression of wild-type Jmjd2c, but not of mutant H190A, increases the expression of Mdm2 oncogene dependent on its demethylase activity, which leads to the reduction of p53 tumor suppressor gene product in the cells Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.11.65 nucleus
-
 Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.65 [histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 Mus musculus Jmjd2c is recruited to the P2 promoter region of Mdm2 gene resulting in demethylation of histone H3 lysine 9, as typically found in actively transcribed genes [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.65 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.65 [histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2
-
 Mus musculus [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
1.14.11.65 [histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 Jmjd2c is recruited to the P2 promoter region of Mdm2 gene resulting in demethylation of histone H3 lysine 9, as typically found in actively transcribed genes Mus musculus [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.65 Jmjd2c histone demethylase
-
 Mus musculus