Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Muha, V.; Zagyva, I.; Venkei, Z.; Szabad, J.; Vertessy, B.G.
    Nuclear localization signal-dependent and -independent movements of Drosophila melanogaster dUTPase isoforms during nuclear cleavage (2009), Biochem. Biophys. Res. Commun., 381, 271-275.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.23 expression in Schneider 2 cells Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.1.23 cytoplasm 21 kDa isozyme, the 21 kDa isozyme is excluded from the nuclei during interphase, it is shifted to the nucleus during prophase and forthcoming mitotic steps Drosophila melanogaster 5737
-
3.6.1.23 additional information both isoforms can be present within the nuclear microenvironment, although at different stages of cell cycle by strict timing to the nuclear cleavage phases Drosophila melanogaster
-
-
3.6.1.23 nucleus 23 kDa isozyme, the 21 kDa isozyme is excluded from the nuclei during interphase, it is shifted to the nucleus during prophase and forthcoming mitotic steps Drosophila melanogaster 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.6.1.23 21000
-
 x * 21000, isozyme 1, SDS-PAGE, x * 23000, isozyme 2, SDS-PAGE Drosophila melanogaster
3.6.1.23 23000
-
 x * 21000, isozyme 1, SDS-PAGE, x * 23000, isozyme 2, SDS-PAGE Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.23 dUTP + H2O Drosophila melanogaster an efficient preventive repair pathway, avoiding uracil in DNA, is generally present that keeps cellular dUTP/dTTP levels at a much decreased value to prevent use of dUTP as a building block by DNA polymerases. The enzyme responsible for this sanitizing role is dUTPase, a ubiquitous protein dUMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.23 Drosophila melanogaster
-
 two dUTPase isozymes
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.1.23 embryo at the syncytial blastoderm stage, localization shifts of dUTPase isozymes within embryos, overview Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.23 dUTP + H2O
-
 Drosophila melanogaster dUMP + diphosphate
-
 ?
3.6.1.23 dUTP + H2O an efficient preventive repair pathway, avoiding uracil in DNA, is generally present that keeps cellular dUTP/dTTP levels at a much decreased value to prevent use of dUTP as a building block by DNA polymerases. The enzyme responsible for this sanitizing role is dUTPase, a ubiquitous protein Drosophila melanogaster dUMP + diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.6.1.23 ? x * 21000, isozyme 1, SDS-PAGE, x * 23000, isozyme 2, SDS-PAGE Drosophila melanogaster

Synonyms

EC Number Synonyms Comment Organism
3.6.1.23 dUTPase
-
 Drosophila melanogaster