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Literature summary extracted from

  • Calafat, M.; Larocca, L.; Roca, V.; Hauk, V.; Pregi, N.; Nesse, A.; Perez Leiros, C.
    Vasoactive intestinal peptide inhibits tumor necrosis factor-alpha-induced apoptotic events in acinar cells from non-obese diabetic mice submandibular glands (2009), Arthritis Res. Ther., 11, R53.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.22.56 TNF-alpha induces caspase-3 activation Mus musculus
3.4.22.61 additional information PBOX-21/STI571 induces activation of caspase-8 leading to aopotosis Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.61 N-carbobenzyloxy-IETD-fluoromethyl ketone a caspase-8 imhibitor, reduces the apoptotic rate in LAMA84 cells by about 50%, and prevents pro-caspase-8 cleavage Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.56 additional information Mus musculus nonobese diabetic mouse acinar cells at 16 weeks show increased caspase 3 activity, as well as increased expression of TNF-alpha receptor1, increased Bax, tumour protein 53-induced nuclear protein1alpha, and chromatin condensation, apoptosis patterns, overview ?
-
 ?
3.4.22.61 additional information Mus musculus caspase-8 is a executioner or downstream caspase. Apoptosis induced by PBOX-21/STI571 results in activation of caspase-8, cleavage of PARP and Bcl-2, upregulation of the pro-apoptotic protein Bim and a downregulation of Bcr-Abl, important role for caspase-8 in the apoptotic pathway, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.56 Mus musculus
-
 nonobese diabetic female BALB/c mice
-
3.4.22.61 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.22.61 proteolytic modification procaspase-8 cleavage to active caspase-8 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.56 epithelial cell epithelial acinar cells Mus musculus
-
3.4.22.56 parotid acinar cell epithelial acinar cells, nonobese diabetic mouse acinar cells at 16 weeks show increased caspase 3 activity Mus musculus
-
3.4.22.56 submandibular gland
-
 Mus musculus
-
3.4.22.61 K-562R cell STI571-resistant cells Mus musculus
-
3.4.22.61 LAMA-84 cell
-
 Mus musculus
-
3.4.22.61 parotid acinar cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.56 acetyl-Asp-Glu-Val-Asp-4-nitroanilide + H2O
-
 Mus musculus acetyl-Asp-Glu-Val-Asp + 4-nitroaniline
-
 ?
3.4.22.56 additional information nonobese diabetic mouse acinar cells at 16 weeks show increased caspase 3 activity, as well as increased expression of TNF-alpha receptor1, increased Bax, tumour protein 53-induced nuclear protein1alpha, and chromatin condensation, apoptosis patterns, overview Mus musculus ?
-
 ?
3.4.22.56 additional information caspase-3 causes chromatin condensation through DNA fragmentation Mus musculus ?
-
 ?
3.4.22.61 additional information caspase-8 is a executioner or downstream caspase. Apoptosis induced by PBOX-21/STI571 results in activation of caspase-8, cleavage of PARP and Bcl-2, upregulation of the pro-apoptotic protein Bim and a downregulation of Bcr-Abl, important role for caspase-8 in the apoptotic pathway, overview Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.56 caspase 3
-
 Mus musculus
3.4.22.61 More caspases form a family of cysteine proteases Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.22.56 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.22.56 7.5
-
 assay at Mus musculus