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Literature summary extracted from
- Mammalian epoxide hydrolases in xenobiotic metabolism and signalling (2009), Arch. Toxicol., 83, 297-318.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.3.2.9 | N-acetylaminofluorene | - |
Mus musculus |  |
| 3.3.2.9 | N-acetylaminofluorene | - |
Homo sapiens | |
| 3.3.2.9 | Phenobarbitone | - |
Mus musculus | |
| 3.3.2.9 | Phenobarbitone | - |
Homo sapiens | |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.3.2.10 | medicine | sEH is a target for the treatment of hypertension, inflammatory diseases, pain, diabetes, and stroke | Homo sapiens |
| 3.3.2.10 | medicine | sEH is a target for the treatment of hypertension, inflammatory diseases, pain, diabetes, and stroke | Mus musculus |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.3.2.9 | expressed in Escherichia coli | Mus musculus |
| 3.3.2.9 | expressed in Escherichia coli | Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.3.2.10 | K55R | the sEH variant K55R has increased epoxide hydrolase activity and is associated with coronary artery disease | Homo sapiens |
| 3.3.2.10 | K55R | the sEH variant K55R has increased epoxide hydrolase activity and is associated with coronary artery disease | Mus musculus |
| 3.3.2.10 | R287Q | the R287Q mutation results in sEH protein with reduced stability and reduced epoxide hydrolase activity, as well as decreased ability of homodimer formation | Homo sapiens |
| 3.3.2.10 | R287Q | the R287Q mutation results in sEH protein with reduced stability and reduced epoxide hydrolase activity, as well as decreased ability of homodimer formation | Mus musculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.3.2.9 | elaidamide | - |
Homo sapiens | |
| 3.3.2.9 | elaidamide | - |
Mus musculus | |
| 3.3.2.9 | trichloropropene oxide | - |
Homo sapiens | |
| 3.3.2.9 | trichloropropene oxide | - |
Mus musculus | |
| 3.3.2.9 | valpromide | - |
Homo sapiens | |
| 3.3.2.9 | valpromide | - |
Mus musculus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.3.2.9 | microsome | - |
Mus musculus | - |
- |
| 3.3.2.9 | microsome | - |
Homo sapiens | - |
- |
| 3.3.2.10 | cytosol | - |
Homo sapiens | 5829 | - |
| 3.3.2.10 | cytosol | - |
Mus musculus | 5829 | - |
| 3.3.2.10 | peroxisome | in some cell types sEH shows a dual localisation, both cytosolic and peroxisomal | Homo sapiens | 5777 | - |
| 3.3.2.10 | peroxisome | in some cell types sEH shows a dual localisation, both cytosolic and peroxisomal | Mus musculus | 5777 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.3.2.9 | additional information | Mus musculus | mEH is capable of inactivating a large number of structurally different, highly reactive epoxides and hence is an important part of the enzymatic defence of our organism against adverse effects of foreign compounds | ? | - |
? | |
| 3.3.2.9 | additional information | Homo sapiens | mEH is capable of inactivating a large number of structurally different, highly reactive epoxides and hence is an important part of the enzymatic defence of our organism against adverse effects of foreign compounds | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.3.2.9 | Homo sapiens | - |
- |
- |
| 3.3.2.9 | Mus musculus | - |
- |
- |
| 3.3.2.10 | Homo sapiens | - |
- |
- |
| 3.3.2.10 | Mus musculus | P34914 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.3.2.9 | liver | high expression level of mEH in the liver | Mus musculus | - |
| 3.3.2.9 | liver | high expression level of mEH in the liver | Homo sapiens | - |
| 3.3.2.10 | brain | - |
Homo sapiens | - |
| 3.3.2.10 | brain | - |
Mus musculus | - |
| 3.3.2.10 | heart | - |
Homo sapiens | - |
| 3.3.2.10 | heart | - |
Mus musculus | - |
| 3.3.2.10 | kidney | - |
Homo sapiens | - |
| 3.3.2.10 | kidney | - |
Mus musculus | - |
| 3.3.2.10 | liver | - |
Homo sapiens | - |
| 3.3.2.10 | liver | - |
Mus musculus | - |
| 3.3.2.10 | lung | - |
Homo sapiens | - |
| 3.3.2.10 | lung | - |
Mus musculus | - |
| 3.3.2.10 | ovary | - |
Homo sapiens | - |
| 3.3.2.10 | ovary | - |
Mus musculus | - |
| 3.3.2.10 | whole body | sEH is highly expressed throughout the body | Homo sapiens | - |
| 3.3.2.10 | whole body | sEH is highly expressed throughout the body | Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.3.2.9 | (5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O | i.e. 11,12-EET | Mus musculus | (5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid | i.e. 11,12-DHET | ? | |
| 3.3.2.9 | (5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O | i.e. 11,12-EET | Homo sapiens | (5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid | i.e. 11,12-DHET | ? | |
| 3.3.2.9 | aflatoxin-B1-8,9-exo-epoxide + H2O | - |
Mus musculus | ? | - |
? | |
| 3.3.2.9 | aflatoxin-B1-8,9-exo-epoxide + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.3.2.9 | benzo[a]pyrene-7,8-epoxide + H2O | - |
Mus musculus | benzo[a]pyrene-7,8-dihydrodiol | - |
? | |
| 3.3.2.9 | benzo[a]pyrene-7,8-epoxide + H2O | - |
Homo sapiens | benzo[a]pyrene-7,8-dihydrodiol | - |
? | |
| 3.3.2.9 | carbamazepine-10,11-epoxide + H2O | - |
Mus musculus | ? | - |
? | |
| 3.3.2.9 | carbamazepine-10,11-epoxide + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.3.2.9 | cis-stilbene oxide + H2O | - |
Mus musculus | (1R,2R)-1,2-diphenylethane-1,2-diol | - |
? | |
| 3.3.2.9 | cis-stilbene oxide + H2O | - |
Homo sapiens | (1R,2R)-1,2-diphenylethane-1,2-diol | - |
? | |
| 3.3.2.9 | ethylene oxide + H2O | - |
Mus musculus | ethane-1,2-diol | - |
? | |
| 3.3.2.9 | ethylene oxide + H2O | - |
Homo sapiens | ethane-1,2-diol | - |
? | |
| 3.3.2.9 | additional information | mEH is capable of inactivating a large number of structurally different, highly reactive epoxides and hence is an important part of the enzymatic defence of our organism against adverse effects of foreign compounds | Mus musculus | ? | - |
? | |
| 3.3.2.9 | additional information | mEH is capable of inactivating a large number of structurally different, highly reactive epoxides and hence is an important part of the enzymatic defence of our organism against adverse effects of foreign compounds | Homo sapiens | ? | - |
? | |
| 3.3.2.9 | styrene oxide + H2O | - |
Mus musculus | 1-phenylethane-1,2-diol | - |
? | |
| 3.3.2.9 | styrene oxide + H2O | - |
Homo sapiens | 1-phenylethane-1,2-diol | - |
? | |
| 3.3.2.9 | styrene-7,8-oxide + H2O | - |
Mus musculus | 1-phenylethane-1,2-diol | - |
? | |
| 3.3.2.9 | styrene-7,8-oxide + H2O | - |
Homo sapiens | 1-phenylethane-1,2-diol | - |
? | |
| 3.3.2.10 | (5Z,11Z,14Z)-8,9-epoxyeicosa-5,11,14-trienoic acid + H2O | i.e. 8,9-EET | Homo sapiens | (5Z,11Z,14Z)-8,9-dihydroxyeicosa-5,11,14-trienoic acid | i.e. 8,9-DHET | ? | |
| 3.3.2.10 | (5Z,11Z,14Z)-8,9-epoxyeicosa-5,11,14-trienoic acid + H2O | i.e. 8,9-EET | Mus musculus | (5Z,11Z,14Z)-8,9-dihydroxyeicosa-5,11,14-trienoic acid | i.e. 8,9-DHET | ? | |
| 3.3.2.10 | (5Z,8Z,11Z)-14,15-epoxyeicosa-5,8,11-trienoic acid + H2O | i.e. 14,15-EET | Homo sapiens | (5Z,8Z,11Z)-14,15-dihydroxyeicosa-5,8,11-trienoic acid | i.e. 14,15-DHET | ? | |
| 3.3.2.10 | (5Z,8Z,11Z)-14,15-epoxyeicosa-5,8,11-trienoic acid + H2O | i.e. 14,15-EET | Mus musculus | (5Z,8Z,11Z)-14,15-dihydroxyeicosa-5,8,11-trienoic acid | i.e. 14,15-DHET | ? | |
| 3.3.2.10 | (5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O | i.e. 11,12-EET | Homo sapiens | (5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid | i.e. 11,12-DHET | ? | |
| 3.3.2.10 | (5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O | i.e. 11,12-EET | Mus musculus | (5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid | i.e. 11,12-DHET | ? | |
| 3.3.2.10 | (8Z,11Z,14Z)-5,6-epoxyeicosa-8,11,14-trienoic acid + H2O | i.e. 5,6-EET | Homo sapiens | (8Z,11Z,14Z)-5,6-dihydroxyeicosa-8,11,14-trienoic acid | i.e. 5,6-DHET | ? | |
| 3.3.2.10 | (8Z,11Z,14Z)-5,6-epoxyeicosa-8,11,14-trienoic acid + H2O | i.e. 5,6-EET | Mus musculus | (8Z,11Z,14Z)-5,6-dihydroxyeicosa-8,11,14-trienoic acid | i.e. 5,6-DHET | ? | |
| 3.3.2.10 | hepoxilin A3 + H2O | excellent substrate for sEH | Homo sapiens | ? | - |
? | |
| 3.3.2.10 | hepoxilin A3 + H2O | excellent substrate for sEH | Mus musculus | ? | - |
? | |
| 3.3.2.10 | hepoxilin B3 + H2O | excellent substrate for sEH | Homo sapiens | ? | - |
? | |
| 3.3.2.10 | hepoxilin B3 + H2O | excellent substrate for sEH | Mus musculus | ? | - |
? | |
| 3.3.2.10 | leukotoxin + H2O | - |
Homo sapiens | leukotoxin diol | - |
? | |
| 3.3.2.10 | leukotoxin + H2O | - |
Mus musculus | leukotoxin diol | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.3.2.9 | dimer | - |
Mus musculus |
| 3.3.2.9 | dimer | - |
Homo sapiens |
| 3.3.2.10 | homodimer | - |
Homo sapiens |
| 3.3.2.10 | homodimer | - |
Mus musculus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.3.2.9 | EPHX1 | - |
Mus musculus |
| 3.3.2.9 | EPHX1 | - |
Homo sapiens |
| 3.3.2.9 | mEH | - |
Mus musculus |
| 3.3.2.9 | mEH | - |
Homo sapiens |
| 3.3.2.10 | EPHX2 | - |
Homo sapiens |
| 3.3.2.10 | EPHX2 | - |
Mus musculus |
| 3.3.2.10 | SEH | - |
Homo sapiens |
| 3.3.2.10 | SEH | - |
Mus musculus |
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