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Literature summary extracted from

  • Jirawattanapong, W.; Saifah, E.; Patarapanich, C.
    Synthesis of glabridin derivatives as tyrosinase inhibitors (2009), Arch. Pharm. Res., 32, 647-654.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 3'',4''-dihydroglabridin 100% inhibition at 0.33 mg/ml Agaricus bisporus
1.14.18.1 glabridin 99.8% inhibition at 0.33 mg/ml Agaricus bisporus
1.14.18.1 kojic acid 76.41% inhibition at 0.33 mg/ml Agaricus bisporus
1.14.18.1 additional information not inhibited by glabridin diacetate, glabridin dihexanoate, glabridin didecanoate, glabridin dipalmitate, and glabridin distearate Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-tyrosine + L-dopa + O2
-
 Agaricus bisporus L-dopa + dopaquinone + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 tyrosinase
-
 Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 0.0114
-
 in 20 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 3'',4''-dihydroglabridin
1.14.18.1 0.01476
-
 in 20 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus kojic acid
1.14.18.1 0.01858
-
 in 20 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus glabridin