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Literature summary extracted from

  • Vandock, K.P.; Smith, S.L.; Fioravanti, C.F.
    Midgut mitochondrial transhydrogenase in wandering stage larvae of the tobacco hornworm, Manduca sexta (2008), Arch. Insect Biochem. Physiol., 69, 118-126.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.1.2 N,N'-dicyclohexylcarbodiimide 0.3 mM significantly inhibits the the energy-linked NADH-NADP+ reactions, but not the nonenergy-linked NADH-NADP+ transhydrogenation Manduca sexta
1.6.1.2 rotenone with rotenone addition, the NADH-NADP+ activity is inhibited significantly and the remaining activity reflects the nonenergy-linked reaction Manduca sexta

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.1.2 mitochondrial membrane
-
 Manduca sexta 31966
-

Organism

EC Number Organism UniProt Comment Textmining
1.6.1.2 Manduca sexta
-
 tobacco hornworm
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.1.2 midgut
-
 Manduca sexta
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.1.2 NADP+ + NADH
-
 Manduca sexta NADPH + NAD+
-
 r
1.6.1.2 NADPH + 3-acetylpyridine-NAD(P)+
-
 Manduca sexta NADP+ + 3-acetylpyridine-NAD(P)H
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.6.1.2 mitochondrial transhydrogenase
-
 Manduca sexta

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.6.1.2 7.5
-
-
 Manduca sexta

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
1.6.1.2 4 6 activity decreases as the pH approaches 6.0, although a second minor peak is evident at pH 5.0, the activity of the nonenergy-linked reaction decreases with medium acidification and activity loss is most notable at pH 4.0 Manduca sexta