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Literature summary extracted from

  • MacDonald, M.J.; Longacre, M.J.; Kendrick, M.A.
    Mitochondrial malic enzyme (ME2) in pancreatic islets of the human, rat and mouse and clonal insulinoma cells (2009), Arch. Biochem. Biophys., 488, 100-104.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.38 fumarate
-
 Rattus norvegicus
1.1.1.38 fumarate
-
 Homo sapiens
1.1.1.38 fumarate
-
 Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.38 ATP
-
 Homo sapiens
1.1.1.38 ATP
-
 Mus musculus
1.1.1.38 ATP
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.38 mitochondrion
-
 Rattus norvegicus 5739
-
1.1.1.38 mitochondrion
-
 Homo sapiens 5739
-
1.1.1.38 mitochondrion
-
 Mus musculus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.38 Homo sapiens P23368
-
-
1.1.1.38 Mus musculus Q99KE1
-
-
1.1.1.38 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.38 INS-1 832/13 cell
-
 Rattus norvegicus
-
1.1.1.38 insulinoma cell
-
 Rattus norvegicus
-
1.1.1.38 insulinoma cell
-
 Homo sapiens
-
1.1.1.38 insulinoma cell
-
 Mus musculus
-
1.1.1.38 pancreatic islet
-
 Rattus norvegicus
-
1.1.1.38 pancreatic islet
-
 Homo sapiens
-
1.1.1.38 pancreatic islet
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.38 (S)-malate + NAD+
-
 Rattus norvegicus pyruvate + CO2 + NADH
-
 ?
1.1.1.38 (S)-malate + NAD+
-
 Homo sapiens pyruvate + CO2 + NADH
-
 ?
1.1.1.38 (S)-malate + NAD+
-
 Mus musculus pyruvate + CO2 + NADH
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.38 mitochondrial malic enzyme ME2
-
 Rattus norvegicus
1.1.1.38 mitochondrial malic enzyme ME2
-
 Homo sapiens
1.1.1.38 mitochondrial malic enzyme ME2
-
 Mus musculus
1.1.1.38 mitochondrial NAD(P) malic enzyme ME2
-
 Rattus norvegicus
1.1.1.38 mitochondrial NAD(P) malic enzyme ME2
-
 Homo sapiens
1.1.1.38 mitochondrial NAD(P) malic enzyme ME2
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.38 NAD+ dual cofactor specificity for NAD+ and NADP+, but shows higher affinity for NAD+, mitochondrial malic enzyme ME2 activity is one-third to one-half as active in the presence of a saturating concentration of NADP+ compared to a saturating concentration of NAD+ Rattus norvegicus
1.1.1.38 NAD+ dual cofactor specificity for NAD+ and NADP+, but shows higher affinity for NAD+, mitochondrial malic enzyme ME2 activity is one-third to one-half as active in the presence of a saturating concentration of NADP+ compared to a saturating concentration of NAD+ Homo sapiens
1.1.1.38 NAD+ dual cofactor specificity for NAD+ and NADP+, but shows higher affinity for NAD+, mitochondrial malic enzyme ME2 activity is one-third to one-half as active in the presence of a saturating concentration of NADP+ compared to a saturating concentration of NAD+ Mus musculus