EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
4.1.1.90 | decarboxylated plasma prothrombin | activates the enzyme | Rattus norvegicus | |
4.1.1.90 | endogenous precursor | activates the enzyme | Rattus norvegicus | |
4.1.1.90 | additional information | enzyme activity increases 2-3fold by a vitamin K deficiency or Warfarin treatment | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.1.1.90 | 2,3,5,6-Tetrachloro-4-pyridinol | TCP, anticoagulant action, effective in vitro inhibitor of the carboxylase | Rattus norvegicus | |
4.1.1.90 | 2-chloro-3-phytyl-1,4-naphthoquinone | chloro-K, effective in vivo antagonist of vitamin K, inhibits the enzyme in an competitive fashion | Rattus norvegicus | |
4.1.1.90 | Boc-Ser(OPO4)-Ser(OPO4)-Leu-OMe | inhibits the enzyme apparently competitively with regard to other peptide substrate | Rattus norvegicus | |
4.1.1.90 | CN- | enzyme is blocked by mM concentrations of CN- | Rattus norvegicus | |
4.1.1.90 | Cu2+ | free Cu2+ and Cu2+-complexes inhibit the reaction | Rattus norvegicus | |
4.1.1.90 | ethanol | high concentrations | Rattus norvegicus | |
4.1.1.90 | Hematin | - |
Rattus norvegicus | |
4.1.1.90 | methemoglobin | - |
Rattus norvegicus | |
4.1.1.90 | p-hydroxymercuribenzoate | - |
Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
4.1.1.90 | microsome | - |
Rattus norvegicus | - |
- |
4.1.1.90 | rough endoplasmic reticulum | - |
Rattus norvegicus | 5791 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
4.1.1.90 | additional information | Mn2+, high concentrations significantly decrease or have no effect on Km of a peptide substrate for the enzyme | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.1.90 | additional information | Rattus norvegicus | cis-isomer of vitamin K1, the 2-desmethyl derivative of phylloquinone, MK-1, or menadione (2 -methyl-1,4-naphthoquinone) have little or no activity | ? | - |
? | |
4.1.1.90 | peptidyl-L-glutamate + CO2 + O2 + menaquinone | Rattus norvegicus | - |
? | - |
? | |
4.1.1.90 | peptidyl-L-glutamate + CO2 + O2 + phylloquinone | Rattus norvegicus | - |
peptidyl-4-carboxy L-glutamate + 2,3-epoxyphylloquinone + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.1.1.90 | Rattus norvegicus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
4.1.1.90 | difficult, different methods shown | Rattus norvegicus |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
4.1.1.90 | peptidyl-4-carboxyglutamate + 2,3-epoxyphylloquinone + H2O = peptidyl-glutamate + CO2 + O2 + phylloquinol | in the physiological process reaction runs in reversed direction | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
4.1.1.90 | bone | - |
Rattus norvegicus | - |
4.1.1.90 | cartilage | - |
Rattus norvegicus | - |
4.1.1.90 | fibroblast | - |
Rattus norvegicus | - |
4.1.1.90 | kidney | - |
Rattus norvegicus | - |
4.1.1.90 | kidney cell line | - |
Rattus norvegicus | - |
4.1.1.90 | liver | - |
Rattus norvegicus | - |
4.1.1.90 | lung | - |
Rattus norvegicus | - |
4.1.1.90 | pancreas | - |
Rattus norvegicus | - |
4.1.1.90 | placenta | - |
Rattus norvegicus | - |
4.1.1.90 | spleen | - |
Rattus norvegicus | - |
4.1.1.90 | tendon | - |
Rattus norvegicus | - |
4.1.1.90 | testis | - |
Rattus norvegicus | - |
4.1.1.90 | thymus | - |
Rattus norvegicus | - |
4.1.1.90 | thyroid | - |
Rattus norvegicus | - |
4.1.1.90 | uterus | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.1.90 | additional information | cis-isomer of vitamin K1, the 2-desmethyl derivative of phylloquinone, MK-1, or menadione (2 -methyl-1,4-naphthoquinone) have little or no activity | Rattus norvegicus | ? | - |
? | |
4.1.1.90 | peptidyl-L-glutamate + CO2 + O2 + menaquinone | - |
Rattus norvegicus | ? | - |
? | |
4.1.1.90 | peptidyl-L-glutamate + CO2 + O2 + phylloquinone | - |
Rattus norvegicus | peptidyl-4-carboxy L-glutamate + 2,3-epoxyphylloquinone + H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.1.1.90 | peptidyl-glutamate 4-carboxylase | - |
Rattus norvegicus |
4.1.1.90 | peptidyl-glutamate 4-carboxylase (2-methyl-3-phytyl-1,4-naphthoquinone-epoxidizing) | - |
Rattus norvegicus |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
4.1.1.90 | 37 | - |
enzyme is not very stable at 37°C and lower temperatures are more desirable. At temperatures below 20°C, extended linear rates of incorporation of 14CO2 into exogenous peptide substrates can be observed | Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
4.1.1.90 | 7.2 | 7.4 | assay at. The activity falls off sharply above pH 8 or below pH 7 | Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
4.1.1.90 | vitamin K | - |
Rattus norvegicus |