Literature summary extracted from

Yatabe, T.; Mochizuki, S.; Takizawa, M.; Chijiiwa, M.; Okada, A.; Kimura, T.; Fujita, Y.; Matsumoto, H.; Toyama, Y.; Okada, Y.
Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes (2009), Ann. Rheum. Dis., 68, 1051-1058.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.4.24.82	interleukin-1alpha	induced gene expression in osteoarthritic chondrocytes	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.24.82	hyaluronan	hyaluronan 800 kDA and 2700 kDa decreased IL1alpha-induced expression of aggrecanase-1 decreased	Homo sapiens
3.4.24.82	KB-R7785	-	Homo sapiens
3.4.24.82	TIMP3	-	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.82	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.24.82	articular cartilage	-	Homo sapiens	-
3.4.24.82	chondrocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.24.82	aggrecan + H2O	100 microg/ml	Homo sapiens	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.24.82	ADAMTS4	-	Homo sapiens
3.4.24.82	aggrecanase-1	-	Homo sapiens

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Release 2023.1 (January 2023)