Literature summary extracted from

Shanks, E.J.; Ong, H.B.; Robinson, D.A.; Thompson, S.; Sienkiewicz, N.; Fairlamb, A.H.; Frearson, J.A.
Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase (2010), Anal. Biochem., 396, 194-203.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.5.1.33	expressed as N-terminal His6-tagged protein in Spodoptera frugiperda 21 cells	Trypanosoma brucei

Crystallization (Commentary)

EC Number	Crystallization (Comment)	Organism
1.5.1.33	-	Trypanosoma brucei

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.5.1.33	methotrexate	-	Trypanosoma brucei

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.5.1.33	Trypanosoma brucei	O76290	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
1.5.1.33	-	Trypanosoma brucei

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.5.1.33	dihydrobiopterin + NADPH	-	Trypanosoma brucei	5,6,7,8-tetrahydrobiopterin + NADP+	-	r

Synonyms

EC Number	Synonyms	Comment	Organism
1.5.1.33	pteridine reductase 1	-	Trypanosoma brucei
1.5.1.33	PTR1	-	Trypanosoma brucei

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
1.5.1.33	0.0000111	-	methotrexate	-	Trypanosoma brucei

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Release 2023.1 (January 2023)