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Literature summary extracted from

  • Moore, K.B.; Saudek, C.D.
    Therapeutic potential of dipeptidyl peptidase-IV inhibitors in patients with diabetes mellitus (2008), Am. J. Ther., 15, 484-491.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.14.5 saxagliptin highly potent and selective inhibitor of DPP-IV Homo sapiens
3.4.14.5 sitagliptin selective inhibitor of DPP-IV, over 80% inhibition of DPP-IV with a single oral dose of 50 mg Homo sapiens
3.4.14.5 vildagliptin highly potent and stable selective inhibitor of DPP-IV, over 90% inhibition of DPP-IV with a single oral dose of 100 mg Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.14.5 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.14.5 breast
-
Homo sapiens
-
3.4.14.5 endothelial cell
-
Homo sapiens
-
3.4.14.5 intestine
-
Homo sapiens
-
3.4.14.5 kidney most densely located in the kidney Homo sapiens
-
3.4.14.5 liver
-
Homo sapiens
-
3.4.14.5 lymphocyte
-
Homo sapiens
-
3.4.14.5 macrophage
-
Homo sapiens
-
3.4.14.5 ovary
-
Homo sapiens
-
3.4.14.5 placenta
-
Homo sapiens
-
3.4.14.5 thyroid gland
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.14.5 glucagon-like peptide 1 + H2O
-
Homo sapiens ?
-
?
3.4.14.5 glucose-dependent insulinotropic peptide + H2O
-
Homo sapiens ?
-
?
3.4.14.5 growth hormone-releasing hormone + H2O
-
Homo sapiens ?
-
?
3.4.14.5 neuropeptide Y + H2O
-
Homo sapiens ?
-
?
3.4.14.5 peptide YY + H2O
-
Homo sapiens ?
-
?
3.4.14.5 pituitary adenylate cyclase activating peptide + H2O
-
Homo sapiens ?
-
?
3.4.14.5 Substance P + H2O
-
Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.14.5 dipeptidyl peptidase-IV
-
Homo sapiens
3.4.14.5 DPP-IV
-
Homo sapiens