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Literature summary extracted from

  • Dayal, S.; Rodionov, R.N.; Arning, E.; Bottiglieri, T.; Kimoto, M.; Murry, D.J.; Cooke, J.P.; Faraci, F.M.; Lentz, S.R.
    Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia (2008), Am. J. Physiol. Heart Circ. Physiol., 295, H816-H825.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.3.18 additional information tissue-specific decrease of levels of Ddah1 and Ddah2 RNA after feeding a high-methionine/low-folate diet for 5 to 11 month Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.5.3.18 Mus musculus
-
 heterozygous for cystathionine beta-synthase and wild-type
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.3.18 aorta
-
 Mus musculus
-
3.5.3.18 brain
-
 Mus musculus
-
3.5.3.18 carotid artery
-
 Mus musculus
-
3.5.3.18 endothelial cell line MS-1 Mus musculus
-
3.5.3.18 kidney
-
 Mus musculus
-
3.5.3.18 liver
-
 Mus musculus
-
3.5.3.18 lung
-
 Mus musculus
-
3.5.3.18 pancreatic islet
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.3.18 0.9
-
 mice fed the high-methionine/low folate diet, heterozygous cystathionine beta-synthase Mus musculus
3.5.3.18 1.1
-
 mice fed the high-methionine/low folate diet, homozygous cystathionine beta-synthase Mus musculus
3.5.3.18 1.6
-
 mice fed the control diet Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.3.18 N,N-dimethyl-L-arginine + H2O 37°C, 2 h, pH 6.0 Mus musculus dimethylamine + L-citrulline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.3.18 DDAH two seperate DDAH-proteins: Ddah1 and Ddah2 Mus musculus
3.5.3.18 dimethylarginine dimethylaminohydrolase
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.3.18 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.3.18 6.9
-
 assay at Mus musculus