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Literature summary extracted from
- Biochemical and physiological function of stearoyl-CoA desaturase (2009), Am. J. Physiol. Endocrinol. Metab., 297, E28-E37.
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.19.1 | Fe2+ | required for activity | Mus musculus |  |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.14.19.1 | 37000 | - |
SDS-PAGE | Mus musculus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.19.1 | Mus musculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.19.1 | brain | isoform SCD-2 is predominantly expressed in brain | Mus musculus | - |
| 1.14.19.1 | brown adipose tissue | isoform SCD-1 | Mus musculus | - |
| 1.14.19.1 | hair follicle | isoform SCD-2 | Mus musculus | - |
| 1.14.19.1 | harderian gland | isoform SCD-1 | Mus musculus | - |
| 1.14.19.1 | heart | isoforms SCD-1 and SCD-4 | Mus musculus | - |
| 1.14.19.1 | kidney | isoforms SCD-1 and SCD-2 | Mus musculus | - |
| 1.14.19.1 | liver | isoform SCD-1 | Mus musculus | - |
| 1.14.19.1 | lung | isoforms SCD-1 and SCD-2 | Mus musculus | - |
| 1.14.19.1 | meibomian gland | isoform SCD-1 | Mus musculus | - |
| 1.14.19.1 | preputial gland | isoform SCD-1 | Mus musculus | - |
| 1.14.19.1 | sebocyte | isoform SCD-1 | Mus musculus | - |
| 1.14.19.1 | skin | isoforms SCD-1, SCD-2, and SCD-3 | Mus musculus | - |
| 1.14.19.1 | spleen | isoforms SCD-1 and SCD-2 | Mus musculus | - |
| 1.14.19.1 | white adipose tissue | isoform SCD-1 | Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.19.1 | palmitoyl-CoA + ferrocytochrome b5 + O2 | - |
Mus musculus | palmitoleoyl-CoA + ferricytochrome b5 + H2O | - |
? | |
| 1.14.19.1 | stearoyl-CoA + ferrocytochrome b5 + O2 | - |
Mus musculus | oleoyl-CoA + ferricytochrome b5 + H2O | - |
? | |
| 1.14.19.1 | stearoyl-CoA + NADH + H+ + O2 | - |
Mus musculus | oleoyl-CoA + NAD+ + H2O | - |
? | |
| 1.14.19.1 | stearoyl-CoA + NADPH + H+ + O2 | - |
Mus musculus | oleoyl-CoA + NADP+ + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.19.1 | SCD-1 | isoform | Mus musculus |
| 1.14.19.1 | SCD-2 | isoform | Mus musculus |
| 1.14.19.1 | SCD-3 | isoform | Mus musculus |
| 1.14.19.1 | SCD-4 | isoform | Mus musculus |
| 1.14.19.1 | stearoyl-CoA desaturase | - |
Mus musculus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.19.1 | cytochrome b5 | - |
Mus musculus | |
| 1.14.19.1 | NADH | - |
Mus musculus | |
| 1.14.19.1 | NADPH | - |
Mus musculus | |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 1.14.19.1 | Mus musculus | isoform SCD-1 expression is dramatically induced in liver and heart in response to high-carbohydrate diet, SCD-1 expression is also induced by nuclear sterol regulatory element-binding protein-1 via the sterol regulatory element in its promoter, in aortic endothelial cells liver X receptor beta activation increases SCD-1 mRNA and protein expression | up |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.14.19.1 | metabolism | SCD is critical in the biosynthesis of triglycerides, cholesterol esters, wax esters, and 1-alkyl-2,3-diacylglycerol | Mus musculus |
| 1.14.19.1 | physiological function | SCD-1 knockout mice show reduced body adiposity, increased insulin sensitivity, leanness, increased metabolic rate, and resistance to diet-induced obesity | Mus musculus |
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Release 2023.1 (January 2023)
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