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Literature summary extracted from
- Angiotensin converting enzyme inhibition enhances collateral artery remodeling in rats with femoral artery occlusion (2008), Am. J. Med. Sci., 335, 177-187.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | medicine | ACE inhibition is a therapeutic target in treating peripheral occlusive arterial disease | Rattus norvegicus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.15.1 | quinapril | 18 mg/kg quinapril per day feeding for 3 days significantly reduces blood plasma ACE activity by 80%, quinapril administration for 16 days greatly decreases blood plasma ACE activity by 88% with 18 mg/kg per day, ACE activities in the heart, lung, and skeletal muscles of the 16-day ACE-inhibition with 18 mg/kg per day are 9%, 16%, and 22% of the controls, respectively | Rattus norvegicus |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.15.1 | angiotensin I + H2O | Rattus norvegicus | - |
angiotensin II + L-His-L-Leu | - |
? | |
| 3.4.15.1 | bradykinin + H2O | Rattus norvegicus | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.15.1 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.15.1 | blood plasma | - |
Rattus norvegicus | - |
| 3.4.15.1 | heart | - |
Rattus norvegicus | - |
| 3.4.15.1 | lung | - |
Rattus norvegicus | - |
| 3.4.15.1 | skeletal muscle | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.15.1 | angiotensin I + H2O | - |
Rattus norvegicus | angiotensin II + L-His-L-Leu | - |
? | |
| 3.4.15.1 | bradykinin + H2O | - |
Rattus norvegicus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | ACE | - |
Rattus norvegicus |
| 3.4.15.1 | angiotensin converting enzyme | - |
Rattus norvegicus |
| 3.4.15.1 | DCP | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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