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Literature summary extracted from

  • Minniti, A.N.; Cataldo, R.; Trigo, C.; Vasquez, L.; Mujica, P.; Leighton, F.; Inestrosa, N.C.; Aldunate, R.
    Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans (2009), Aging Cell, 8, 690-705.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.11 Caenorhabditis elegans
-
-
-
1.8.4.11 Caenorhabditis elegans N2
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.4.11 hypodermis weak expression in the hypodermis Caenorhabditis elegans
-
1.8.4.11 intestine the msra-1 gene is expressed in most tissues, particularly in the intestine Caenorhabditis elegans
-
1.8.4.11 nervous system the msra-1 gene is expressed in most tissues, particularly in the nervous system Caenorhabditis elegans
-
1.8.4.11 neuron occasional expression in neurons Caenorhabditis elegans
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.11 dabsyl-L-methionine (S)-sulfoxide + thioredoxin
-
 Caenorhabditis elegans ?
-
 ?
1.8.4.11 dabsyl-L-methionine (S)-sulfoxide + thioredoxin
-
 Caenorhabditis elegans N2 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.11 methionine sulfoxide reductase A
-
 Caenorhabditis elegans
1.8.4.11 MsrA
-
 Caenorhabditis elegans
1.8.4.11 MSRA-1
-
 Caenorhabditis elegans

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.4.11 thioredoxin
-
 Caenorhabditis elegans

Expression

EC Number Organism Comment Expression
1.8.4.11 Caenorhabditis elegans msra-1 mRNA is increased by 2fold in daf-2 mutants compared to wild type controls when worms are cultured at 23 and 25°C, there is a notorious increase in MSRA-1 activity in daf-2 mutants as the worms age, at 23°C MSRA-1 expression is dramatically enhanced in the nervous system up

General Information

EC Number General Information Comment Organism
1.8.4.11 physiological function MSRA-1 is involved in the aging process in Caenorhabditis elegans, worms carrying a deletion of the msra-1 gene are more sensitive to oxidative stress, show chemotaxis and locomotory defects, and a 30% decrease in median survival Caenorhabditis elegans