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Literature summary extracted from

  • Sun, H.Y.; Szlam, F.; Levy, J.H.; Csete, M.E.; Tanaka, K.A.
    Antifibrinolytic agents reduce tissue plasminogen activator-mediated neuronal toxicity in vitro (2009), Acta Anaesthesiol. Scand., 53, 325-331.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.68 drug development antifibrinolytic agents may be useful for protecting neurons when tPA-mediated damage is anticipated synthetic construct

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.68 Aprotinin mitigates tPA-induced neuronal injury. Pre-treatment of N27 cells with aprotinin for 30 min before tPA exposure is protective against cell death, increasing the cell viability to 91.8% at a tPA concentration of 20 microg/ml. When aprotinin treatment follows tPA exposure, cell death is proportional to the length of tPA exposure synthetic construct
3.4.21.68 bivalirudin does not exert any protective effect when added at concentrations of 20-200 microg/ml (cell viability of 51.8%) synthetic construct
3.4.21.68 epsilon-aminocaproic acid mitigates tPA-induced neuronal injury synthetic construct
3.4.21.68 Glu-Gly-Arg-chlormethylketone directly binds to the catalytic site of tPA. 100 microg/ml given before tPA exposure, reduces cell death (cell viability of 80.5%) synthetic construct
3.4.21.68 Phe-Pro-Arg-chlormethylketone directly binds to the catalytic site of tPA. 100 microg/ml given before tPA exposure, reduces cell death (cell viability of 85.7%) synthetic construct

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.68 synthetic construct
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.68 additional information tPA induces N27 neuroblast cell death in a dose-and time-dependent manner synthetic construct ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.68 Tissue plasminogen activator
-
 synthetic construct
3.4.21.68 tPA
-
 synthetic construct