Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Kong, L.; Li, S.; Han, X.; Xiang, Z.; Fang, X.; Li, B.; Wang, W.; Zhong, H.; Gao, J.; Ye, L.
    Inhibition of HCV RNA-dependent RNA polymerase activity by aqueous extract from Fructus Ligustri Lucidi (2007), Virus Res., 128, 9-17.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.7.48 medicine NS5B is strictly required for viral replication and thus represents an attractive therapeutic target Hepacivirus C

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.48 Fructus Ligustri Lucidi aqueous extract 0.005 mg/ml, inhibits intracellular NS5B-catalyzed RNA synthesis Hepacivirus C

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.48 Hepacivirus C
-
 HepG2, Hep3B, and Bel-7402 cells transfected with
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.48 nucleoside triphosphate + RNAn
-
 Hepacivirus C diphosphate + RNAn+1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.48 NS5B
-
 Hepacivirus C
2.7.7.48 RDRP
-
 Hepacivirus C
2.7.7.48 RNA-dependent RNA polymerase
-
 Hepacivirus C