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Literature summary extracted from

  • Sandilands, E.; Frame, M.C.
    Endosomal trafficking of Src tyrosine kinase (2008), Trends Cell Biol., 18, 322-329.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.10.2 additional information autophosphorylation of Y416 leads to the activation of c-Src Homo sapiens

Application

EC Number Application Comment Organism
2.7.10.2 medicine overexpressed or activated Src is present in a high percentage of tumours, Src has therefore been an target for the development of anti-cancer therapies Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.2 additional information phosphorylation of Y527 leads to the inactivation of c-Src, negative regulation Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.10.2 endosome
-
 Homo sapiens 5768
-
2.7.10.2 plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 ATP + [protein]-L-tyrosine Homo sapiens
-
 ADP + [protein]-L-tyrosine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.10.2 phosphoprotein
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.2 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 ATP + [protein]-L-tyrosine
-
 Homo sapiens ADP + [protein]-L-tyrosine phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 Src tyrosine kinase
-
 Homo sapiens